Poster Topical Area: Dietary Bioactive Components

Location: Hall D

Poster Board Number: 308

P08-050 - Anti-inflammatory Effects of Cinnamon in a Mouse Model of Dextran Sulfate Sodium-induced Colitis

Monday, Jun 11
8:00 AM – 3:00 PM

Objective: This study aimed to evaluate the anti-inflammatory effects of cinnamon on colitis induced by 5% dextran sulfate sodium (DSS) in Balb/c mice.

Methods: The experimental animals were divided into five groups: control, DSS-induced colitis, 100 300, and 500 ㎎/㎏ of cinnamon. The mice were fed distilled water or cinnamon extracts once a day for 21 days. Colitis was induced from day 14 to 21 by administration of 5% DSS in drinking water. We evaluated the change in weight, colon length, and the pathological disease activity index (DAI).

Results: Compared to the mice in the DSS group, those in the cinnamon groups showed an increase in body weight at 21 days. The cinnamon extracts significantly decreased the shortening of the colon. The length of the colon of mice receiving 500 mg/kg cinnamon increased to 9.8 cm, whereas that of the mice receiving DSS was 8.0 cm. The mean DAI in the cinnamon groups was significantly lower than that in the DSS group since day 4. Administration of 500 mg/kg cinnamon was associated with the highest decrease in the DAI by 0.375 points.

Conclusions: Our results indicate that cinnamon has protective effects against DSS-induced colitis. Therefore, we concluded that cinnamon may be used for the prevention and treatment of irritable bowel syndrome (IBD).

Funding Source:

This work was supported by Korea Institute of Planning and Evaluation for Technology in Food, Agriculture, Forestry and Fisheries (IPET) through High Value-added Food Technology Development Program, funded by Ministry of Agriculture, Food and Rural Affairs (MAFRA) (Project No. 116012-3).

CoAuthors: Ji Sun Youn – Seoul National University of Science and Technology; Min Seo Kim – Seoul National University of Science and Technology; Ji Yeon Kim – Seoul National University of Science and Technology; Yeon Seok Kim – Chunho Bio

Kyeong Jin Kim

Graduate student
Seoul National University of Science and Technology
Seoul, Seoul-t'ukpyolsi, Republic of Korea