Poster Topical Area: Nutritional Epidemiology
Location: Hall D
Poster Board Number: 742
Objective: To examine sex-specific associations between SSB intake and elevated systolic blood pressure
Methods: Logistic regression was used to examine associations between quartiles of SSB intake from FFQ data and elevated SBP (>120 mmHg) among 2003-2006 NHANES participants aged 20-74 years (n=2,398). Because of the potential influence of sex-hormones on hypertension, analysis was conducted in men (n=1,367) and women (n=1,031) separately and further dichotomized by menopausal status. Women were classified as premenopausal if menses in past 2 months (n=846); postmenopausal if age >40y and no menses in past 12 months (n=185). Women reporting hysterectomy or oophorectomy or not meeting these criteria were excluded.
Results: A 31% increased risk of elevated SBP was observed in the highest (mean=3.27 servings/day) compared to lowest SSB quartile (mean=0.03 servings/day) after adjustment for sex, age, race, BMI, alcohol use, physical activity, and smoking (OR: 1.31, 95% CI: 0.99-1.73, p= 0.057). In sex-specific analysis, an 89% increased risk of elevated SBP in the highest compared to the lowest SSB quartile was found in women (OR: 1.89, 95% CI: 1.14-3.12, p=0.013) but not men, after adjustments. Similar to men, no association was found in post-menopausal women, however premenopausal women had over a two fold increase in risk of elevated SBP in the highest compared to lowest SSB intake quartile (OR: 2.42, 95% CI: 1.35-4.36, p= 0.003).
Conclusions: The association between higher SSB intake and increased risk of hypertension for pre- but not for post-menopausal women and men may suggest a role of sex hormones in this relationship and indicates the need to conduct analysis of nutrition and cardiometabolic outcomes by menopausal status.
University of Massachusetts Amherst