Poster Topical Area: Energy and Macronutrient Metabolism

Location: Hall D

Poster Board Number: 461

P10-061 - Effects of MCDG and equivalent intakes of long-chain triacylglycerol oils as part of muffins on postprandial lipid metabolism

Monday, Jun 11
8:00 AM – 3:00 PM

Objective: We assessed the ability of medium-chain diacylglycerol (MCDG) oils to lower levels of postprandial triglycerides (TGs) and plasma fatty acids.

This double-blind, randomized, cross-over trial evaluated effects of MCDG oils on the postprandial metabolic responses in healthy men and women with normal weight (n=28). Each subject carried out a meal tolerance test twice over during the study period with a seven-day interval. Muffins that contained 15 g of MCDG oils (MCDG muffins, test products) or long-chain triacylglycerol (LCT) oils (LCT muffins, placebo products) were used for the meal tolerance test. Blood samples were collected at a fasting condition (0 hr) and at 2, 3, 4, and 6 hr after ingestion of the muffins.

Postprandial TG levels were significantly lower at 3 and 4 hr after consuming the MCDG muffins compared to the LCT muffins. Postprandial chylomicron-TG levels were significantly lower at 4 hr after consuming the MCDG muffins compared to the LCT muffins. The area under the curve (AUC) of postprandial TG and chylomicron-TG decreased approximately 13% when the subjects ingested MCDG muffins rather than LCT muffins. Postprandial levels of plasma fatty acids including palmitic acid, stearic acid, and linoleic acid were decreased after MCDG muffin intake compared to LCT muffin intake.

These results indicate that dietary MCDG oils decreased postprandial TGs, chylomicron-TGs, and plasma fatty acids compared to dietary LCT oils. This might be due to metabolic characteristics of MCDG oil in the digestive tract.

Funding Source: This study was supported by the Bio-Synergy Research Project (NRF-2012M3A9C4048762), the Mid-Career Researcher Program (NRF-2016R1A2B4011662), the Basic Science Research Program (NRF-2017R1C1B2007195) through the National Research Foundation of Korea (NRF) funded by the Ministry of Science, ICT & Future Planning.

CoAuthors: Minkyung Kim – Yonsei University; Hye Jin Yoo – Yonsei University; Ayoung Lee – Yonsei University; Jong Ho Lee – Yonsei University

Minjoo Kim

Yonsei University
Seoul, Seoul-t'ukpyolsi, Republic of Korea