Poster Topical Area: Nutritional Epidemiology
Location: Hall D
Poster Board Number: 787
Objective: Cardiovascular disease (CVD) is the leading cause of death in the U.S. C-reactive protein (CRP) is one of the inflammatory biomarkers for CVD risk. Vitamin B6 deficiency has been associated with increased CVD risks, and shown to reduce the plasma concentrations of n-3 polyunsaturated fatty acids (PUFAs). N-3 PUFAs may reduce CVD risks by modulating the production of inflammatory mediators. The purpose of this study was to investigate whether dietary intakes of n-3 PUFAs and vitamin B6 were associated with serum CRP concentrations in older and younger adults from a U.S. representative sample.
Methods: Cross-sectional data from the National Health and Nutrition Examination Survey (NHANES) cycle 2003-2004 ages 20-39 and 40-80+ years were analyzed. The final sample size n=4258 in the dietary target nutrient analysis (ages 20-39: n=1461; 40-80+: n=2797) were included. Associations of dietary intakes of vitamin B6 and n-3 PUFAs (eicosapentaenoic acid (EPA)+docosahexaenoic acid (DHA)) with serum CRP levels were assessed using multiple regression models accounting for the complex survey design and weighting of NHANES with SAS, version 9.4 (SAS Institute Inc., Cary, NC, USA). The level of significance was p <0.05.
Results: There were significant negative associations of dietary vitamin B6 with serum CRP in both age groups [20-39] (β-coefficient=-0.042, 95% confidence interval (CI)= [-0.080, -0.004], p=0.03) and [40-80+] (β-coefficient=-0.071, CI= [-0.107, -0.034], p=0.001). There were also significant negative associations of dietary n-3 PUFAs with serum CRP in both age groups [20-39] (β-coefficient=-0.059, CI= [-0.110, -0.007], p=0.028) and [40-80+] (β-coefficient=-0.085, CI= [-0.153, -0.017], p=0.017).
Conclusion: Higher intakes of vitamin B6 and n-3 PUFAs were associated with lower CRP concentrations. Adequate intakes of vitamin B6 and n-3 PUFAs may have protective effects against CVD outcomes. Prospective studies for dietary intakes of vitamin B6 and n-3 PUFAs are needed to confirm these associations.
Florida International University