Poster Topical Area: Nutrient-Gene Interactions

Location: Hall D

Poster Board Number: 431

P17-008 - Gender differences in the perception of salty taste. Effect of the SCNN1B-rs239345 polymorphism and its use for Mendelian randomization in a European population

Sunday, Jun 10
8:00 AM – 6:00 PM

Aims: To find out whether there is a difference in the perception of salty taste between men and women of a similar age in a general Mediterranean population and to analyze the influence of the rs239345 in the Sodium Channel Epithelial 1 Beta Subunit (SCNN1B), a candidate gene for salty taste perception and to assess whether this polymorphism would be a good proxy of salty taste for Mendelian randomized studies.
Methods: We analyzed 661 women and 368 men in a general Spanish population from the OBENUTIC study (mean age: 43+/-8 y.). All were administered a direct tasting of of substances representing the different tastes (the intensity of perception was noted on a 0 to 5 scale).
Results: Women significantly perceived a greater intensity of salty, sour and bitter taste. There were no differences in sweet and umami. At a 200mM-NaCl, mean of salty taste was 2.3+/-1.3 points in men vs 2.7+/-1.3 in women (P<0.000001). This difference remained statistically significant after adjusting for weight, diabetes and lifestyle variables. The polymorphism was significantly and recessively associated with greater salty taste perception (+0.35 units for NaCl 200mM in homozygous subjects of the variant allele; P=0.030). No heterogeneity per gender was observed. Thus, it could be a good indicator of greater salty taste perception for use in Mendelian randomization. However, bearing in mind that many tastes are interrelated, we analyzed the association between the polymorphism and the perception of other tastes and obtained a greater association with sweet taste perception (sucrose 400mM), +0.53 units in homozygous subjects (P=0.001). Conclusions: Women perceived more salty taste than men. Despite the rs239345 being significantly associated with greater salty taste perception, its great perception with sweet taste adds pleitropy and limits its use as a proxy of salty taste in Mendelian randomization studies.

Funding Source: CIBEROBN (ISCIII, Madrid, Spain), PROMETEO17/2017 (Generalitat Valenciana, Valencia, Spain)

CoAuthors: Olga Portoles – University of Valencia; Jose Sorli – University of Valencia and CIBEROBN; Jose Gonz├ílez – University of Valencia; Carolina Ortega – CIBEROBN; Oscar Coltell – Valencia University_UJI-CIBEROBN; Esther Ferriz – Valencia University; Eva Asensio – University of Valencia; Rocio Barragan – CIBER OBN

Dolores Corella

University of Valencia and CIBEROBN
Valencia, Comunidad Valenciana, Spain