Poster Topical Area: Nutritional Epidemiology

Location: Hall D

Poster Board Number: 795

P20-114 - Higher BMI is Associated with Higher CD4 Cell Count and Metabolic Syndrome in the Miami Adult Studies in HIV (MASH) Cohort

Sunday, Jun 10
8:00 AM – 6:00 PM

Background: During the pre-antiretroviral therapy (ART) era, higher body mass index (BMI) was shown to have a beneficial effect on HIV disease progression. However, results from studies on the relationship between BMI and CD4 cell recovery in adults on ART are inconsistent. In the general population, the risk for cardiovascular disease increases with higher BMI. The objective of this study was to evaluate the relationship between body composition, CD4 cell count, a measure of HIV disease progression, and metabolic syndrome (MS) in HIV+ adults in the MASH cohort in Miami, Florida.


Methods:
A cross-sectional analysis of data from an observational longitudinal study was conducted in 251 HIV+ adults on ART. Anthropometrics and bioimpedance were obtained. Blood was drawn for lipid panel and CD4 count was obtained from medical records. MS was defined as having ≥3 of the following factors: waist circumference >102 cm in men or 89 cm in women, triglycerides ≥150 mg/dL, high density lipoprotein cholesterol ≤40 mg/dL in men or ≤50 mg/dL in women; blood pressure ≥130/85 mmHg; and serum glucose ≥100 mg/dL. Wilcoxon, chi-square and logistic regression analyses were completed.


Results:
The median age was 53 years (IQR=49-58) and 59% were male. Those with a BMI ≥25 kg/m2 compared to those will a lower BMI had higher median levels of CD4 cell count [614 (IQR=365-882) vs. 411 cells/µL (IQR=314-706), P=0.002]. This relationship remained significant up to a BMI cut-off of 37 kg/m2 (P=0.05). A body fat mass of >25% for men or 31% for women was also associated with higher median CD4 cell counts [640 (IQR=356-869) vs. 532 cells/µL (IQR=310-724), P=0.016]. In a linear regression model adjusting for age and gender, BMI was associated with CD4 cell count (β=0.16, SE=0.07, P=0.026). BMI >30 kg/m2 was associated with a 4.9 greater odds of having MS than lower BMI (OR=4.87, 95% CI: 2.55, 9.31, P


Conclusions:
We confirmed a direct relationship between increased BMI, body fat mass and CD4 cell count in an HIV infected population on ART. However, we showed a direct relationship between BMI with MS, which raises the risk for cardiovascular disease and other conditions such as diabetes and stroke. Additional research is needed to observe the interaction of HIV and obesity overtime on morbidity and mortality.




Funding Source: National Institute on Drug Abuse/NIH

CoAuthors: Adriana Campa – Florida International University; Qingyun Liu – Florida International University; Leslie Seminario – Florida International Unviersity; Jupshy Jasmin – Florida International University; Jacqueline Hernandez – Florida International University; Alicia Sneij – Florida International University; Alhanoof Alohaly – Florida International University; Colby Teeman – Florida International University; Javier Tamargo – Florida International University; Angelique Johnson – Florida International University; Marinana Baum – Florida International University

Sabrina SALES.. Martinez

Assistant Professor
Florida International University
Miami, Florida