Poster Topical Area: Neurobiology
Location: Hall D
Poster Board Number: 699
Background: Currently there are no established preventive strategies for Alzheimer's disease (AD). Adherence to healthy dietary patterns is related to better cognition and lower risk of AD in older adults. Brain is rich in fat-soluble nutrients that have been individually reported to be related to cognitive health in older adults. Since cognition and AD development are complex biological outcomes, synergistic effects of nutrients on cognitive health remain to be characterized.
Objectives: The primary objective is to characterize fat-soluble nutrient patterns (FSNPs) in the brain and evaluate their relationship to cognitive functions.
Methods: Brain samples from the frontal (FC) and temporal cortices (TC) were obtained from 47 centenarian decedents who were enrolled in the Georgia Centenarian Study. Subjects underwent a battery of cognitive tests every six months until mortality. Cognitive tests from the time point closest to death were used to calculate cognitive domain scores. Brain carotenoids, retinoids, tocopherols were quantified by high performance liquid chromatography equipped with photodiode array detector. Brain fatty acids (FAs) were quantified by gas chromatography coupled with flame ionization detector. Nutrient levels in the FC and TC were averaged. FSNPs were identified separately in subjects with (n = 24) and without (n = 23) dementia using principal component analysis. The relationship between FSNPs and cognitive domain scores was evaluated by Pearson's correlation analysis with an adjustment for sex, education, diabetes, and hypertension.
Results: Among non-demented subjects, a FSNP characterized by high levels of carotenoids, saturated FAs, n-3 polyunsaturated FAs, and low levels of retinoids, monounsaturated FAs, n-6 polyunsaturated FAs, trans-FAs was significantly (p < 0.05) related to cognitive domain scores including memory (r = 0.57), executive function (r = 0.57), language (r = 0.70), global cognition (r = 0.62), and activities of daily living (r = 0.55). No consistent relationship was observed in demented subjects.
Conclusion: Brain FSNP is related to a wide range of cognitive measures in older adults with no dementia. Findings from this research provide a rationale for developing dietary therapies aimed at prevention of AD and cognitive impairments.