Poster Topical Area: Medical Nutrition

Location: Hall D

Poster Board Number: 649

P14-024 - Dietary supplement with amino acids and chromium picolinate decreases postprandial glucose: a meta-analysis of controlled trials

Monday, Jun 11
8:00 AM – 3:00 PM

Objectives
Water containing amino acids (AA) and chromium picolinate (CrPic) has been shown to improve postprandial glucose in healthy individuals in controlled trials. To substantiate results and explore subgroups of individuals in which these effects are pronounced, a pooled analysis of three studies was performed.

Methods

Data from randomized, placebo-controlled, single (1) and double blinded (2) studies were pooled to include 82 lean and overweight (BMI < 30 kg/m²) healthy individuals. Twenty-three subjects were studied in the US, 23 in Canada and 36 in Sweden. Participants received a test breakfast meal containing 46-50 g of available carbohydrates and 7-14 g protein. The test product was the commercially available Good Idea® water or a late prototype. Good Idea® contains 2.6g AA (Leu, Ile, Val, Lys, Thr) and 250µg CrPic as well as carbonation and flavoring. The placebo drink was identical with respect to water, carbonation and flavoring. Subjects consumed 350ml of Good Idea® or placebo starting 3 minutes prior to the meal. Glucose and insulin responses were measured and incremental areas under the curve (iAUC) were calculated up to 3h after a meal and compared using a paired T-Test. This analysis focuses on 2h iAUC values.

Results

Good Idea® reduced the iAUC for glucose significantly by 28% (43.0±37.7 vs. 59.4±50.4mmol*min/l, p=0.002) and the maximum blood glucose by 5% (6.0±0.8 vs. 6.3±0.9 mmol/l, p<0.001). Significant correlations of change in iAUC glucose with BMI (R=0.34 p<0.01) and age (R=0.26 p<0.05) were found. Women had a more pronounced glucose reduction (-33%; n=42; p=0.01), whereas the reduction in men was 22% (n=40; p=0.10). The insulin curves with GoodIdea® shifted somewhat to the left, yet maximum insulin and the insulin iAUCs were not significantly different between groups.

Conclusions

This meta-analysis shows the potential of Good Idea® to reduce postprandial glucose after a carbohydrate rich meal. There seem to be influences of age, BMI and gender on this effect that will have to be further investigated. In addition, it needs to be clarified whether regular consumption of Good Idea may favorably influence surrogate markers of metabolic disease, overall caloric intake or even reduce the risk of developing diabetes.


Funding Source: Glucanova AB

CoAuthors: Kristina Anderson – Aventure AB, Lund, Sweden; Lovisa Heyman-Lindén – Aventure AB; Rickard Öste – Aventure AB; Per Humpert – Stoffwechselzentrum Rhein-Pfalz; Elin Östman – Aventure AB

Azat Samigullin

Research Physician
starScience GmbH
Heidelberg, Baden-Wurttemberg, Germany