Poster Topical Area: Aging and Chronic Disease
Poster Board Number: 92
Objective: The aim of this study was to evaluate the association between habitual coffee consumption and subclinical atherosclerosis measured as coronary artery calcium (CAC) in the Brazilian Longitudinal Study of Adult Health (ELSA-Brasil).
Methods: This is a cross-sectional study based on baseline data from participants of the cohort ELSA-Brasil.Only participants living in São Paulo with no prior history of CVD who underwent a CAC measurement (n=4,426) were included. Dietary data were collected and included the number of 50 mL cups of coffee consumed regularly using a validated food frequency questionnaire. Coronary calcification was detected with computed tomographic and it was expressed as Agatston units. CAC was further categorized as an Agatson score of ≥100.
Results: In multiple logistic regression analysis considering intake of coffee and smoking status interaction, significant inverse associations were observed between coffee consumption (>3 cups/day) and CAC≥100. The adjusted odds ratio (OR) and 95% confidence interval for CAC ≥100 in subjects who consumed coffee compared with those who never drank coffee were 0.85 (0.58-1.24) for ≤ 1 cup/day, 0.73 (0.51-1.05) for 1-3 cups/day, and 0.33 (0.17-0.65) for >3 cups/day (P for trend=0.015). Moreover, there was a statistically significant interaction effect for coffee consumption and smoking status (P for interaction=0.028). After stratification by smoking status the analysis revealed lower OR of coronary calcification in never smokers drinking >3 cups/day (OR 0.37, 95% CI: 0.15-0.91), whereas among current and former smokers the intake of coffee was not significantly associated with coronary calcification.
Conclusions: The current study suggests that habitual consumption of more than 3 cups of coffee per day decreased odds of subclinical atherosclerosis, among never smokers. Thus, the consumption of coffee could exert a potential beneficial effect against coronary calcification, particularly in non-smokers.
The ELSA-Brasil baseline study was supported by the Brazilian Ministry of Health (Science and Technology Department) and the Brazilian Ministry of Science and Technology and National Research Council (grant numbers 01 06 0010.00 RS, 01 06 0212.00 BA, 01 06 0300.00 ES, 01 06 0278.00 MG, 01 06 0115.00 SP, and 01 06 0071.00 RJ). The research center of São Paulo was also supported by Sao Paulo Research Foundation (FAPESP) (grant number 2011/12256-4). A.M.M. received scholarship from the Sao Paulo Research Foundation (FAPESP).
School of Public Health, University of Sao Paulo
São Paulo, Sao Paulo, Brazil