Poster Topical Area: Aging and Chronic Disease

Location: Auditorium

Poster Board Number: 39

P01-018 - Dietary Magnesium Intake, Vitamin D Status and Parathyroid Hormone: Influence on Cardiometabolic Health in Overweight and Obese Adults

Sunday, Jun 10
8:00 AM – 6:00 PM





Objective: Poor magnesium (Mg) status may impair glycemic control, alter lipid metabolism, and increase parathyroid hormone (PTH) production, thereby leading to increased risk of cardiometabolic diseases. Low dietary Mg intake, combined with elevated serum PTH (sPTH) concentrations and low serum 25-hydroxyvitamin D (s25OHD) concentrations, are frequently observed in individuals living with overweight and obesity (Owt/Ob). Extracellular Mg can regulate PTH secretion by modulating calcium surface receptors on parathyroid glands. Furthermore, transportation and activation of s25OHD requires Mg as a cofactor. The objective of this study was to examine the relationship between dietary Mg intake, s25OHD status, PTH concentrations, and cardiometabolic disease risks in Owt/Ob adults.




Methods:
A total of 38 Owt/Ob men and women with a body mass index (BMI) between 25 to 45 kg/m2 and ages 22 to 66 years participated in this study. Blood samples were obtained for analyses of s25OHD, sPTH, total triglycerides, insulin, fasting glucose, serum ionized Mg, and inflammatory cytokines to determine cardiometabolic risk factors. Body composition information was measured using dual energy x-ray absorptiometry (DXA). Dietary Mg intake was measured using a magnesium food frequency questionnaire (MgFFQ).




Results:
The mean Mg intake of our participants was 258.23 ± 170.5 mg per day. Eighty-one percent of the participants in this study fell below the recommended dietary allowance for Mg. A higher Mg intake was significantly (p = 0.009) associated with a lower serum fasting glucose (r = -0.502). Participants with a higher dietary Mg intake also tended to have a lower BMI, higher serum 25OHD, and lower PTH concentrations. There was no observable relationship between Mg intake and body composition.




Conclusion:
A higher dietary Mg intake may lower cardiometabolic disease risk in an Owt/Ob population. Intervention trials focused on Mg repletion will provide a better insight into the role of Mg in improving cardiometabolic health.




Funding Source: Scientist Development Grant to D Sukumar from the American Heart Association

CoAuthors: Rosemary DeLuccia – Drexel University; Abeer Aljahdali – Drexel University; Rohit Ramadoss – Drexel University; Deeptha Sukumar – Drexel University

May M. Cheung

Doctoral Candidate
Drexel University
Philadelphia, Pennsylvania