Poster Topical Area: Energy and Macronutrient Metabolism

Location: Hall D

Poster Board Number: 477

P10-077 - Dyslipidemia Risk and Saturated Fat Intake from Records of Patients who Receive Precision Ketogenic Therapy

Monday, Jun 11
8:00 AM – 3:00 PM

Objectives: Precision Ketogenic Therapy (PKT) is a high fat, low carbohydrate, adequate protein diet that is used to treat seizures in patients with refractory epilepsy. Research has suggested that ketogenic diets may increase risk for dyslipidemia. The objective of this work was to determine if saturated fat intake was higher among patients who developed dyslipidemia on PKT.

Methods: This was a cross-sectional analysis of patients who were referred to the University of Florida PKT Program from 1995-2016. Caregivers were provided with recipes and were instructed to weigh all food to the nearest tenth of a gram. Patients were included for this analysis if they had a fasting lipid panel and diet records at any time point on PKT through 24 months. The Mann-Whitney test was used to compare each lipid parameter from baseline to 6, 12, 18, and 24 months on PKT. PKT ratio (grams of fat: grams of protein and carbohydrate) and saturated fat (SFA) intake (% of total fat) were compared between records of patients who had acceptable or unacceptable lipids on PKT.

Results: Patients remained on PKT for a median of 1.2 years (N=55). There were no significant differences in total cholesterol (TC), non-HDL, or LDL from baseline to any time point on PKT. HDL was lower at 12 and 18 months on PKT compared to baseline (P<0.01), but remained acceptable for the majority of patients. Triglycerides (TG) were higher at 6, 12, and 18 months on PKT compared to baseline for patients who were <10 years old (P<0.01). Diet intake data were available from 13,580 records collected on PKT. There were no differences in PKT ratio intake for patients with acceptable or unacceptable lipids. SFA intake (% of total fat) was lower for patients with acceptable TC at 6 and 12 months on PKT compared to patients with high TC (Table 1). There were no differences in SFA intake (% of total fat) between patients with acceptable or high TG.

Conclusions: Lowering saturated fat intake can improve TC levels for patients who receive PKT. Future work should explore the relationship between dietary fatty acid intake and the increase in TG patients experience on PKT.

Funding Source:

University of Florida Foundation (KetoGator, Fund ID: 018555).

Research reported in this publication was supported by the University of Florida Clinical and Translational Science Institute, which is supported in part by the NIH National Center for Advancing Translational Sciences under award number UL1TR001427. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health.

TABLE 1 SFA intake (% of total fat) over time on PKT for patients with acceptable or high TC

CoAuthors: Peggy Borum, PhD – University of Florida

Jurate Lukosaityte

PhD Student
University of Florida
Gainesville, Florida