Poster Topical Area: Nutritional Epidemiology

Location: Hall D

Poster Board Number: 840

P20-179 - Association of Individual Saturated Fatty Acids Intake with Total Mortality in A Nationwide Prospective Cohort Study

Monday, Jun 11
8:00 AM – 3:00 PM

Objectives: Whether dietary intake of saturated fatty acids (SFAs) associate with total mortality in Chinese nationwide population remains unknown. We aimed to evaluate the association between individual SFAs intake and total mortality in Chinese.

We analyzed data of 14,383 participants between 1989 and 2009 from the China Health and Nutrition Survey (CHNS). Cumulative averages of SFAs intake were calculated based on 3-day 24-hr recalls in each survey year. Multivariate Cox proportional hazard regression models were used to evaluate hazard ratios (HRs) and 95% confidence intervals (CIs).

During a median of 14 years of follow-up, 1,011 deaths were documented. In men, relationships between total SFAs (TSFAs) and even-chain SFAs with total mortality appeared U-shaped, with the lowest HR in the third quartile [HRQ3 vs Q1 (95% CI): 0.58 (0.43, 0.80) for TSFAs and 0.57 (0.42, 0.79) for even-chain SFAs]. In contrast, higher even-chain SFAs intake were associated with an increased risk of death in women [HRQ4 vs Q1 (95% CI): 1.75 (1.05, 2.91); P-trend = 0.03]. Notably, total mortality was inversely associated with the intake of odd-chain SFAs in men [HRQ4 vs Q1 (95% CI): 0.62 (0.46, 0.83); P-trend = 0.01] and women [0.54 (0.38, 0.77); P-trend < 0.001]. Furthermore, intake of median-chain SFAs (MCSFAs) was related to a lower total mortality in men [HRQ4 vs Q1 0.64 (0.44, 0.93); P-trend = 0.06]. An increased total mortality was observed in men when replacing unsaturated fatty acids with even-chain SFAs, especially 16:0 and stearic acid (18:0).

Moderate TSFAs intake may reduce total mortality in men. High even-chain SFAs intake may increase total mortality in women whereas odd-chain SFAs intake is associated with a lower total mortality in both genders. Our findings provide epidemiological evidence for improving dietary guidelines for Chinese.

Funding Source: This work was supported by the National Natural Science Foundation of China [grant number 81773419] and Chinese Institute of Nutrition DSM Research Fund (CNS-DSM-2017-035).
Multivariate-adjusted hazard ratios for associations between total SFAs and subtypes of total SFAs intake and total mortality in Chinese

Multivariate-adjusted HRs (95% CIs) of total mortality by replacing 100mg of PUFA or MUFA with equal amount of SFAs

CoAuthors: Jingjing Jiao – Zhejiang University School of Medicine; Yu Zhang – Zhejiang University

Pan Zhuang

PhD student
College of Biosystems Engineering and Food Science, Zhejiang University
Hangzhou, Zhejiang, China (People's Republic)