Poster Topical Area: Diet and Cancer
Poster Board Number: 200
Objectives: We aimed to evaluate the association between dietary patterns and nutrients and colorectal cancer in developing country settings in Ethiopia.
Method: We conducted a hospital based matched case–control study, including 88 CRC patients and 264 controls in Addis Ababa. Dietary habits were assessed by a 70-item semi quantitative food frequency questionnaire (FFQ). We used factor analysis methods to identify dietary patterns. Nutrient content of food was calculated using nutrisurvey software. A conditional Logistic regression was used to evaluate the association of diet patterns, intakes of total energy, macronutrients and alcohol with CRC risk. We used nutrient residual model to control effect of total energy intake.
Result: Principal components factor analysis identified 8 primary dietary patterns: a fruit diet pattern, a refined cereal diet pattern, a dairy diet pattern, a grain diet pattern, a pulse diet pattern, a fish diet pattern, a red meat diet pattern, and alcohol drinks pattern. After adjusting for confounding factors, the meat-diet and the refined cereal-diet increased the risk of CRC with corresponding odds ratios (ORs) of 2.7 (95% CI: 1.20- 6.22) and 3.1 (95% CI: 1.01- 10.14 for people in the highest intake quintile compared to those in the lowest. Whereas fish-diet pattern and diary-diet pattern decreases the risk of CRC with a corresponding OR of 0.01 (95% CI: 0.002-0.06) and 0.1(95% CI: 0.03-0.27). A significant but weak inverse association was also found for macronutrients and fiber. However, we did not find a significant association between fruit pattern and colorectal cancer.
Conclusion: These results suggest that dietary patterns characterized by a high frequency of meat and refined cereal consumption increased while frequent consumption of fish and dairy foods decreased the risk of colorectal cancer in developing countries such as Ethiopia.
ADDIS ABABA UNIVERSITY
Addisababa, Adis Abeba, Ethiopia