Poster Topical Area: Aging and Chronic Disease
Poster Board Number: 125
Aluminum (Al) is abundant in the earth crust and relatively inert and also the component of certain common used legal food additives. However, there are many diseases related to aluminum toxicity, i.e. Alzheimer's disease, anemia, hyperparathyrodism, osteomalacia, and Parkinson's disease. Norwegian osteoporosis study revealed that relatively high concentration of Al in drinking water increased risk of hip fracture. Other study indicated that Wistar rats fed with Al (100 mg Al3+/L, 90 days) caused disorders of calcium-phosphorus metabolism, lower body weight gain and higher plasma levels of Al. However, there is few study related to body Al content and bone health in Taiwanese population. The purpose of this study is to analyze the associations among blood levels of aluminum, osteoporotic-related minerals, parathyroid hormone (PTH), vitamin D and bone mass density (BMD). Seventy hospitalized patients with fracture for surgery and forty-nine healthy controls were recruited. blood levels of calcium (Ca), phosphorus (P), magnesium (Mg), aluminum (Al), as well as vitamin D and parathyroid hormone(PTH) were examined. Subjects with bone fracture were recruited in 3-5 days right after their surgeries respectively. In the patient group, the results indicated that the fracture patients with lower spine BMD had the higher plasma Al concentration (P=0.04). The average plasma concentration of Al, Mg, Ca, P, PTH and vitamin D were similar in two groups.In addition, plasma Ca concentration was negatively correlated with plasma vitamin D, and PTH (P<0.05). Yet, Eight percent of all subjects have abnormal Al level (above 10 µg/L) in this study. Although there is no association among Al level, other mineral concentration and bone density which may be due to small sample size, the analysis of the exposure of Al might be beneficial for the implementation of clinical care and health education to reduce the risk of osteoporosis in Taiwan.
Ph. D. Program of Nutrition and Food Science
Fu Jen Catholic University
Taipei City, Taipei, Taiwan (Republic of China)