Poster Topical Area: Nutrient-Gene Interactions
Location: Hall D
Poster Board Number: 455
Objectives: Changes in nutrient absorption in patients undergoing Roux-en-Y gastric bypass (RYGB) may influence the telomere lenght (TL). In this context, the main objective of this study was to evaluate the TL in individuals with severe obesity before and after six months of the RYGB.
Methods: We selected 18 women with severe obesity, aged 27 to 50 years, submitted to the RYGB in the pre and postoperative of six months. Anthropometric data (weight and height), body composition and peripheral blood for analysis of TL were collected before and after 6 months of the surgical procedure. The TL was measured by PCR method described by Cawton and obtained by the T/S ratio for each sample [ΔCt = Ct (Tel) - Ct (36B4); T/S ratio = 2 (-ΔCt)]. For statistical analysis, the Shapiro-Wilk tests, paired t-test and Pearson's correlation were used. Statistical significance was set for p<0.05 (Statistical Package for Social Science - SPSS).
Results: A significant difference was observed in body composition in the preoperative period (Fat free mass = FFM (kg): 64.7 ± 7.5; FFM (%): 53.9 ± 6.4; Fat mass = FM (kg): 52.6 ± 10.8 and FM (%): 46.3 ± 5.6) with respect to the postoperative period of six months (FFM (kg): 53.8 ± 7.2 FFM (%): 61.9 ± 7.5, FM (kg): 33.8 ± 9.7 and FM (%): 38.1 ± 7.5, p<0.05). The TL was maintained after six months of surgery (0.888 ± 0.35), when compared to the preoperative period (0.805 ± 0.16, p>0.05).
Conclusion: The lost of weight beneficially changes anthropometric parameters and body composition. However, the amount of weight lost after six months of bariatric surgery is not able to significantly modify the TL.
University of Sao Paulo (USP)
Ribeirão Preto, Sao Paulo, Brazil