Poster Topical Area: Nutrient-Gene Interactions

Location: Hall D

Poster Board Number: 455

P17-032 - Evaluation of telomere length in women with severe obesity submitted to Roux-en-Y gastric bypass

Sunday, Jun 10
8:00 AM – 6:00 PM

Objectives: Changes in nutrient absorption in patients undergoing Roux-en-Y gastric bypass (RYGB) may influence the telomere lenght (TL). In this context, the main objective of this study was to evaluate the TL in individuals with severe obesity before and after six months of the RYGB.

We selected 18 women with severe obesity, aged 27 to 50 years, submitted to the RYGB in the pre and postoperative of six months. Anthropometric data (weight and height), body composition and peripheral blood for analysis of TL were collected before and after 6 months of the surgical procedure. The TL was measured by PCR method described by Cawton and obtained by the T/S ratio for each sample [ΔCt = Ct (Tel) - Ct (36B4); T/S ratio = 2 (-ΔCt)]. For statistical analysis, the Shapiro-Wilk tests, paired t-test and Pearson's correlation were used. Statistical significance was set for p<0.05 (Statistical Package for Social Science - SPSS).

A significant difference was observed in body composition in the preoperative period (Fat free mass = FFM (kg): 64.7 ± 7.5; FFM (%): 53.9 ± 6.4; Fat mass = FM (kg): 52.6 ± 10.8 and FM (%): 46.3 ± 5.6) with respect to the postoperative period of six months (FFM (kg): 53.8 ± 7.2 FFM (%): 61.9 ± 7.5, FM (kg): 33.8 ± 9.7 and FM (%): 38.1 ± 7.5, p<0.05). The TL was maintained after six months of surgery (0.888 ± 0.35), when compared to the preoperative period (0.805 ± 0.16, p>0.05).

The lost of weight beneficially changes anthropometric parameters and body composition. However, the amount of weight lost after six months of bariatric surgery is not able to significantly modify the TL.

Funding Source: Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq).
Fundação de Apoio Ao Ensino, Pesquisa e Assistência do HCFMRP-USP (FAEPA).

CoAuthors: Carolina Nicoletti – University of São Paulo; Vitor Pinhanelli – University of São Paulo; Marcela Pinhel – University of São Paulo; Leticia Wolf – University of São Paulo; Flavia Ferreira – University of São Paulo; Rayana Foglietti – University of São Paulo; Bruno Oliveira – University of São Paulo; Wilson Junior – University of São Paulo; Carla Nonino – University of São Paulo

Caroline R. Welendorf

Master student
University of Sao Paulo (USP)
Ribeirão Preto, Sao Paulo, Brazil