Poster Topical Area: Nutrient-Gene Interactions

Location: Hall D

Poster Board Number: 435

P17-012 - Expression of the Hypocretin-1 gene (Orexin-A) in severely obese women submitted to Roux-en-Y gastric bypass

Sunday, Jun 10
8:00 AM – 6:00 PM

Objective: To verify the expression of the gene of Orexin-A in women with severe obesity submitted to the RYGB.

Methods : Patients were selected in a university hospital and distributed in two groups: Bariatric Group: women with severe obesity (Body mass index - BMI> 35 kg / m²) submitted to surgery, composed of 10 individuals and Control Group: women (BMI between 18.5 and 24.9 kg / m²), composed of 7 individuals. Before and after the surgical procedure, anthropometric data (weight, height, BMI and waist circumference), body composition, food intake (24-hour food recall) and peripheral blood collection were analyzed for Orexin-A gene expression.


Results:
Orexin-A gene expression increased after 6 months of bariatric surgery (5.38 ± 0.1) compared to preoperative period (-1.64 ± 0.08; p> 0.05). Significant reduction was observed in all anthropometric and body composition indicators (p< 0.05).Regarding the indicators of food intake, there were no significant changes.


Conclusion:
Significant weight loss after 6 months of bariatric surgery promotes a considerable increase in Orexin-A gene expression. In addition, it positively aids changes in anthropometric parameters and body composition.




Funding Source: Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
Fundação de Apoio ao Ensino,Pesquisa e Assistência (FAEPA)

CoAuthors: Barbara dos Santos – University of Sao Paulo; Caroline Welendorf – University Of Sao Paulo; Flavia Ferreira – University of Sao Paulo; Leticia Wolf – University of Sao Paulo; Carolina Nicoletti – University of Sao Paulo; Marcela Augusta Pinhel – University of Sao Paulo; Bruno Parenti – University of Sao Paulo; Vitor Pinhanelli – University of Sao Paulo; Carla Nonino – University of Sao Paulo

Rayana Foglietti

Master Student in nutrition and metabolism
University of Sao Paulo
Ribeirao Preto, Sao Paulo, Brazil