Poster Topical Area: Dietary Bioactive Components

Location: Hall D

Poster Board Number: 393

P08-135 - Effects of Dietary Avicularin on Gut Microbiota in Mice

Monday, Jun 11
8:00 AM – 3:00 PM

Objectives: Gut microbiota play an important role in host health, and dysbiosis of gut microbiota is related to many diseases, such as obesity, inflammation, diabetes and cancer. Accumulating evidence indicates that the biological activities of dietary polyphenols are related to their effect on modulating the composition of gut microbiota. The aim of this study was to determine the effects of dietary intake of avicularin, a plant-derived polyphenol commonly found in apple and mango, on the composition of gut microbiota in CD-1 mice.
Methods:
The male CD-1 mice were fed with avicularin in diet (0.1% w/w) with monitoring the body weight, food and water intake, and blood chemistry parameters for 3 weeks. 16S rRNA gene sequencing was utilized for the analysis of gut microbiota community.
Results:
The monitoring indexes during the entire experimental period demonstrated that dietary intake of avicularin did not cause any noticeable adverse effects in the mice. Results of 16S rRNA gene sequencing showed that dietary treatment with avicularin modulated the composition of gut microbiota by significantly reducing the abundance of g_ucispirillum (p < 0.05) whose prevalence was associated with increased inflammation, and decreasing the abundance of two genera of Firmicutes (p < 0.05) that were potentially related to obesity. Furthermore, the levels of short chain fatty acids in colonic contents were greatly increased by dietary avicularin.
Conclusions:
Overall, these results indicated that the dietary intake of avicularin may have beneficial effects on improving homeostasis of gut microbiota.




Funding Source:

The authors are grateful for the scholarship provided by the China Scholarship Council. This work was financially supported by the University of International Cooperation in Science and Technology Innovation Platform Project of Guangdong (Grant No.2013gjhz0003), the National Natural Science Foundation of China (31201321), and education department of Hu nan Province (B13084).

CoAuthors: Min Gu – University of Massachusetts Amherst; Mingyue Song – South China Agricultural University; Yanhui Han – University of Massachusetts, Amherst; Xiaoqiong Cao – University of Massachusetts Amherst; Yong Cao – South China Agricultural University; Hang Xiao – University of Massachusetts Amherst

Xiaoai Zhu

South China Agricultural University, University of Massachusetts Amherst
Amherst, Massachusetts