Poster Topical Area: Nutritional Epidemiology

Location: Hall D

Poster Board Number: 837

P20-172 - Diet intake of nutrients and risk of cervical intraepithelial neoplasia in a Chinese population-based study

Monday, Jun 11
8:00 AM – 3:00 PM

Objective: Dietary nutrients play the significant role in the carcinogenesis. However, few studies had been conducted to evaluate the association of dietary nutrients and risk of cervical intraepithelial neoplasia (CIN) even cervical cancer among community-based Chinese women.


Methods:
We performed a cross-sectional analysis of baseline data in a total of 40000 local resident women (married and age from 19 to 65 year old) in high incidence area of cervical cancer (Shanxi Province, China. PRC). Multivariable logistic regressions were modeled to evaluate the relation of dietary factors with CIN risk. Those women were tested by epidemiological survey, cervical cytological examination (TCT), human papilloma virus (HPV) and vaginal PH test and food frequency questionnaire (FFQ) was used to retrospectively investigate dietary ingredient intake.


Results:
Dietary folate after multiple adjustments was negatively associated with CIN II+ risk (odds ratio [OR]:1.57, 95% confidence interval [CI]: 1.04-2.35). Dietary Vitamin B6 associated with CIN II+ risk (OR: 1.64, 95% CI: 1.09–2.48); the Vitamin C associated with CIN II+ risk (OR: 1.57, 95% CI: 1.03–2.37); the Niacin associated with CIN II+ risk (OR: 1.68, 95% CI: 1.11-2.55); The Vitamin K was significantly associated with CIN II+ risk, albeit displaying a reverse U-shape relationship.


Conclusion:
Dietary nutrients associate with risk of CIN supported the conception that the nutrition shortage of the dietary folate, Vitamin B6, Vitamin C, Niacin, Vitamin K, affected CIN II+ risk in high incidence area of cervical cancer in China. Diet and nutrition factors should be added to risk stratification when counseling women about the risk of carcinogenesis.



Funding Source: Early warning model for the development of cervical intraepithelial neoplasia and multicenter study on the optimization of treatment strategies.

Chinese Clinical Trial Register (ChiCTR), ChiCTR-ROC-15006479
Characteristics of participants with cervical histological examination among 2304 women in the study (n = 2,304)

Characteristics of participants with cervical histological examination among 2304 women in the study (n = 2,304)

ORs and 95% Cls for quintiles of dietary multivitamins intake with cervical intraepithelial neoplasia (grade 1) risk among 2,304 women in the study

ORs and 95% Cls for quintiles of dietary multivitamins intake with cervical intraepithelial neoplasia (grade II+) risk among 2,304 women in the study

ORs and 95% Cls for quintiles of dietary multivitamins intake with cervical intraepithelial neoplasia (grade II+) risk among 2,304 women in the study

CoAuthors: Aimin Yang – School of Public health, The University of Hong Kong, Hong Kong SAR, China; Jing Yang – Department of Obstetrics and Gynecology, Second Hospital of Shanxi Medical University, Taiyuan, China.; Wei Wang – Department of Obstetrics and Gynecology, Second Hospital of Shanxi Medical University, Taiyuan, China.; Zhilian Wang – Department of Obstetrics and Gynecology, Second Hospital of Shanxi Medical University, Taiyuan, China.; Weihong Zhao – Department of Obstetrics and Gynecology, Second Hospital of Shanxi Medical University, Taiyuan, China.; Min Hao – Department of Obstetrics and Gynecology, Second Hospital of Shanxi Medical University, Taiyuan, China.

Zhe Wang

Doctor
Department of Obstetrics and Gynecology, Second Hospital of Shanxi Medical University, Taiyuan, China.
Tai Yuan, Shanxi, China (People's Republic)