Poster Topical Area: Nutritional Epidemiology
Location: Hall D
Poster Board Number: 837
Objective: Dietary nutrients play the significant role in the carcinogenesis. However, few studies had been conducted to evaluate the association of dietary nutrients and risk of cervical intraepithelial neoplasia (CIN) even cervical cancer among community-based Chinese women.
Methods: We performed a cross-sectional analysis of baseline data in a total of 40000 local resident women (married and age from 19 to 65 year old) in high incidence area of cervical cancer (Shanxi Province, China. PRC). Multivariable logistic regressions were modeled to evaluate the relation of dietary factors with CIN risk. Those women were tested by epidemiological survey, cervical cytological examination (TCT), human papilloma virus (HPV) and vaginal PH test and food frequency questionnaire (FFQ) was used to retrospectively investigate dietary ingredient intake.
Results: Dietary folate after multiple adjustments was negatively associated with CIN II+ risk (odds ratio [OR]:1.57, 95% confidence interval [CI]: 1.04-2.35). Dietary Vitamin B6 associated with CIN II+ risk (OR: 1.64, 95% CI: 1.09–2.48); the Vitamin C associated with CIN II+ risk (OR: 1.57, 95% CI: 1.03–2.37); the Niacin associated with CIN II+ risk (OR: 1.68, 95% CI: 1.11-2.55); The Vitamin K was significantly associated with CIN II+ risk, albeit displaying a reverse U-shape relationship.
Conclusion: Dietary nutrients associate with risk of CIN supported the conception that the nutrition shortage of the dietary folate, Vitamin B6, Vitamin C, Niacin, Vitamin K, affected CIN II+ risk in high incidence area of cervical cancer in China. Diet and nutrition factors should be added to risk stratification when counseling women about the risk of carcinogenesis.
Department of Obstetrics and Gynecology, Second Hospital of Shanxi Medical University, Taiyuan, China.
Tai Yuan, Shanxi, China (People's Republic)