Poster Topical Area: Obesity

Location: Hall D

Poster Board Number: 676

P23-049 - Dogs increase lean body mass with dietary carnitine as compared to carnosine supplementation or the combination of carnitine and carnosine

Sunday, Jun 10
8:00 AM – 6:00 PM

Objectives: This study evaluated whether dietary carnitine or carnosine would change lean body mass in dogs.

Methods: Forty eight pets were assigned into four groups: Group 1 (n=12) was fed the control diet, group 2 (n=12) was fed the control diet + L-carnitine (0.03%), group 3 (n=12) was fed the control diet + L-carnosine (0.1%), and Group 4 (n=12) was fed the Control diet + L-carnitine + L-carnosine. The ages of the dogs ranged from 4.0 to 9.1 yr. All study protocols were reviewed and approved by the Institutional Animal Care and Use Committee, Hill's Pet Nutrition, Inc., Topeka, KS. The duration of the study was 6 months. Initial body composition and metabolomics profiles were compared to final and changes were compared across treatments. Metabolomics were measured by Metabolon (Morrisville, NC). Change in lean body mass (LBM) was assessed by dual-energy X-ray absorptiometry (DEXA) and reported in dogs as the difference in LBM between initial and final times.

Results: Lean body mass increased in dogs fed carnitine alone (+402+ 135 g, P< 0.05) when compared to carnosine alone (+152 + 136g) or the combination (+150 + 140g). The non supplemented control (284 + 117g) was intermediate (P>0.10) to all supplemented groups. The control pets lost more body fat (-381 + 152g, P<0.05) than did either the dogs fed carnosine alone (-35 + 175g) or the combination (53 + 177g) with the carnitine alone group being intermediate (-132 + 176g). There was no significant effect of dietary treatments on body weight. Circulating carnitine was increased in the groups that had carnitine supplemented (p<0.05) when compared to the non-supplemented groups. Also, many acyl carnitines were increased in both groups supplemented with carnitine. Circulating carnosine was not changed by dietary carnosine.

Conclusions
: Supplementation of carnitine is more beneficial than the supplementation of carnosine in increasing LBM in canines.






Funding Source: Hill's Pet Nutrition, Inc.

CoAuthors: Kiran Panickar, PhD – Hill's Pet Nutrition; Matthew Jackson, PhD – Hill's Pet Nutrition, Inc.; Matthew Jackson, PhD – Hill's Pet Nutrition, Inc.; Matthew Jackson, PhD – Hill's Pet Nutrition, Inc.

Dennis E. Jewell

Senior Fellow
Hill's Pet Nutrition, Inc
Topeka, Kansas