Poster Topical Area: Energy and Macronutrient Metabolism

Location: Hall D

Poster Board Number: 484

P10-084 - Effect of high or standard-protein low-calorie diets on glucose metabolism and adipokines in diabetic subjects with overweight or obesity

Monday, Jun 11
8:00 AM – 3:00 PM

Objective: To assess the effect of low-calorie diets with normal (18%) vs. high (35%) protein (mainly coming from lean animal source) composition on glucose metabolism and adipokines concentration in overweight and obese subjects with type 2 diabetes.

Design: 73 subjects (43.8% men, 55.6±8.37 aged and 32.8±3.67 of BMI) were randomized to follow one of two calorie-restricted diets with the following distribution of calories from protein, carbohydrates and fat, respectively: 18%, 52% and 30%; 35%, 35%, and 30%, during six months. Anthropometric, clinical, biochemical (including adipokines concentration) and dietary and physical activity assessment was performed at baseline and after 3 and 6-months intervention.


Results:
Weight loss homogenously decreased among diets. Glycemic control showed a greater improvement regardless of weight loss in subjects consuming 35-%-protein diet, including glucose, insulin, HOMA-IR, and HbA1c. HOMA-IR diminished by -23.4±27.7% and -37.7±21.3 after 3-months (P=0.023 comparing both diets), and -20.6±34.6% and -41.7±18.1% after 6-months (P=0.004) with 18%- and 35%-protein diets, respectively. RBP4 and leptin significantly decreased in both diets although no differences were found between diets. Adiponectin significantly increased in both diets; it changed by 6.05% and 29.9% at 3-months in 18%- and 35%-protein diets, respectively (P=0.167), and 23.7% and 53.5% at 6-months in 18%- and 35%-protein diets, respectively (P=0.219). Adiponectin variation was inversely correlated to HbA1c (R=-0.431, PP=0.043) and HOMA-IR (R=-0.262, P=0.047) changes at 6-months.

Conclusions: A 35%-protein energy-restricted diet lead to a greater glucose metabolism improvement, especially observed in HOMA-IR, irrespective of weight loss. Adiponectin levels showed a higher increase after 35%-protein diet although statistical significance was not found. This change was inversely associated to HbA1c, HOMA-IR and insulin variations. Our findings demonstrate that high-protein diets improve glycemic parameters regardless weight loss in diabetic subjects. However, this effect seems not to be explained by changes in plasma concentrations of adipokines.




Funding Source:

This study was supported in part by three grants from the Carlos III Research Institute: CIBERCV (co-supported by the European Regional Development Fund (ERDF) which is allocated by the European Union; IIS16/0114), PI13/02507 and PI15/01983.

CoAuthors: Victoria Marco-Benedí – Hospital Universitario Miguel Servet, Instituto de Investigación Sanitaria Aragón (IIS Aragón), CIBERCV.; Sofia Pérez-Calahorra – Hospital Universitario Miguel Servet, Instituto de Investigación Sanitaria Aragón (IIS Aragón), CIBERCV.; Ana Bea – Hospital Universitario Miguel Servet, Instituto de Investigación Sanitaria Aragón (IIS Aragón), CIBERCV.; Itziar Lamiquiz-Moneo – Hospital Universitario Miguel Servet, Instituto de Investigación Sanitaria Aragón (IIS Aragón), CIBERCV.; Lucia Baila-Rueda – Hospital Universitario Miguel Servet, Instituto de Investigación Sanitaria Aragón (IIS Aragón), CIBERCV.; Ana Cenarro – Hospital Universitario Miguel Servet, Instituto de Investigación Sanitaria Aragón (IIS Aragón), CIBERCV.; Fernando Civeira – Hospital Universitario Miguel Servet, Instituto de Investigación Sanitaria Aragón (IIS Aragón), CIBERCV, Universidad de Zaragoza.

Rocío Mateo-Gallego

Postdoctoral researcher
Hospital Universitario Miguel Servet, Instituto de Investigación Sanitaria Aragón (IIS Aragón), CIBERCV, Universidad de Zaragoza.
Zaragoza, Aragon, Spain