Poster Topical Area: Nutritional Epidemiology
Location: Hall D
Poster Board Number: 765
Objectives: To prospectively examine the association between total alcohol and specific alcoholic beverages consumption and risk of hip fractures in U.S. men and women.
Methods: Health, lifestyle information and hip fractures were self-reported on biennial questionnaires between 1980-2014 in 74,540 post menopausal women from the Nurses' Health Study, and between 1986-2014 in 35,451 men 50 years of age and older from the Health Professionals Follow-up Study. Diet was assessed approximately every 4 years with a food frequency questionnaire. Relative risks (RR) were computed for non-traumatic hip fracture using Cox proportional hazards models, adjusting for potential confounders.
Results: We ascertained 2,360 incident non-traumatic hip fractures in women and 741 in men. Among women, alcohol consumption less than 20g/day was associated with a lower risk of non-traumatic hip fractures compared with non-drinkers (RR for 10 to <20g/d = 0.82, 95%CI=0.71-0.95) but not for quantities 20+g/d (RR=0.91, 95%CI=0.78-1.09). In men, a significant inverse association was observed (RR comparing 20+g/d vs none = 0.71, 95% CI=0.54-0.92, p trend=0.003). An inverse association was observed for red wine among women (RR =0.62, 95% CI=0.48-0.81 for each serving/d). Among drinkers, the lowest risk among women was observed with a consumption pattern of 3-4d/week (RR compared with <1/wk =0.65, 95%CI=0.51-0.84) compared with <1d/wk, even after controlling for total alcohol intake, although we had limited power for those that reported daily drinking. Among men, the lowest risk was observed with 5-7d/wk of consumption (RR=0.68, 95%CI=0.46-0.98). We did not find an association between the maximum number of drinks per drinking occasion in a typical month and risk of non-traumatic hip fractures.
Conclusion: In these two U.S. cohorts, moderate alcohol intake was associated with a lower risk of non-traumatic hip fractures.
This work is funded by National Institutes of Health grants: UM1 CA186107, UM1 CA167552, and AG30521