Poster Topical Area: Diet and Cancer

Location: Auditorium

Poster Board Number: 206

P07-020 - Gender analysis in the development and validation of inflammatory biomarker prediction model.

Monday, Jun 11
8:00 AM – 3:00 PM

Objectives

C-reactive protein (CRP) serves as one of chronic inflammation markers. Because CRP levels and factors associated with CRP levels may differ by gender, we developed index for predicting high-sensitivity CRP (hsCRP) in men and women combined or separately and compared the validities of indices.



Methods

We included a total of 63,594 men and women from the Health Examinees (HEXA) Study. We included hsCRP as a dependent variable and foods, nutrients, and other lifestyle factors as independent variables in stepwise linear regression models to develop the index in the training set. We created 4 versions: 1) foods only; 2) foods and nutrients; 3) foods and other lifestyles, and 4) foods, nutrients and other lifestyles. We assessed agreement and validity of indices with actual hsCRP in the testing set. We calculated spearman correlation and relative concentrations of hsCRP using linear regression analyses. We compared agreement and validity between indices developed in men and women combined (gender-combined) and that developed in men and women separately (gender-specific).



Results

The gender-combined index was calculated from intakes of noodles, nuts, curd, red/yellow vegetables, fermented seafood, and carbonated drinks, alcoholic drinks, menopausal status, smoking status and supplements. In the gender-specific index, intakes of noodles, nuts, fermented seafood, carbonated drinks, and coffee, alcoholic drinks and smoking status were selected in men, and nuts, curd, and red /yellow vegetables, supplements and menopausal status were selected in women. Age, BMI, educational level, and exercise were retained in all indices. Kappa coefficients and spearman correlation between predicted hsCRP index based on foods and other lifestyles and actual hsCRP were the highest among 4 versions of indices. The relative concentrations were 1.68 (95% CI 1.57, 1.79) in men and 2.01 (95% CI 1.87, 2.15) in women when we examined the association for gender-specific index. For gender-combined index, the associations with actual hsCRP levels were similar to those of gender-specific index.



Conclusion

We found that components were different between gender-combined index and gender-specific index. However, the magnitude of association with actual hsCRP was similar between two indices. Our findings warrant further studies.





Funding Source: This research was supported by Support Program for Women in Science, Engineering and Technology through the National Research Foundation of Korea(NRF) funded by the Ministry of Science and ICT(No. 2016H1C3A1903202).

CoAuthors: Sihan Song – College of Human Ecology, Seoul National University; Jung Eun Lee – College of Human Ecology, Seoul National University

Sejin Kim

Graduate student
Seoul National University
Seoul, Seoul-t'ukpyolsi, Republic of Korea