Poster Topical Area: Diet and Cancer

Location: Auditorium

Poster Board Number: 209

P07-023 - Effects of Allium Hookeri extracts on Glucose and Lipid Metabolism in Type II Diabetic Mice

Monday, Jun 11
8:00 AM – 3:00 PM

Allium hookeri(A. hookeri) is a plant species native to India, Sri Lanka, Myanmar, and China. The plant is widely cultivated in Korea lately as a medicinal food item. This study was conducted to verify the potential of Allium hookeri to control blood glucose and lipid metabolism in diabetes model. We fed the experimental diets (AL, AR, Dex) supplemented with the powder of leaf, root, or dextrin as a positive control, respectively at 3% of diet to the diabetic mice (C57BLKS/J, db/db, n=8/group, 5 groups) for 8 weeks. Control mice were fed with the diet supplemented with cornstarch (Cont) at 3% level of diet. At 8th week of feeding the diets, we measured body weight, blood glucose, HbA1c, and plasma insulin levels and conducted an oral glucose tolerance test (OGTT) and staining insulin immunoreactive cells in islets of pancreas. AL group treated with the leaf of A. hookeri showed significantly lower blood glucose and HbA1c levels, higher plasma insulin levels, and increased density of insulin immunoreactive cells compared with the Cont group. During the OGTT, AL group showed lower blood glucose levels than the Cont group for 120 min. Based on these results, leaf of A. hookeri is considered to be effective in improving glucose tolerance by partially affecting insulin secretion
and it may be used to prevent and treat diabetic disease. In the lipid metabolism study of Type II diabetic mice (n=8/group, 5 groups), high fat diets with dextrin as a positive control (Dex), leaf (AL), root (AR), and fermented root (FAR) at 3% of diet were fed to all experimental mouse, respectively for 8 weeks. Body weight gain, liver and epididymal fat weights, and excreted fecal lipid levels were measured. Serum and hepatic lipid profiles were analyzed, and fat accumulation in liver was evaluated. In this study, body weight gain and epididymal fat weight were
lower in the FAR group, while serum HDL-cholesterol level and excreted fecal total lipid and triglyceride levels were higher in AL or FAR groups. These results suggest that A. hookeri, specially fermented root can be a useful food item to control lipid metabolism in diabetic mice.




Funding Source: RDA

CoAuthors: Bong-Kyoum Choi – RDA NAAS; Jung-Bong Kim... – RDA NAAS; Hwan-Hee Jang – RDA NAAS; JeongSuk Choe – RDA NAAS; Yousuk Kim – Gold Tree; Hyun-Ju Kim – WIKIM

Sung Hyen Lee

Scientist
RDA NAAS
Wanju, Cholla-bukto, Republic of Korea