Poster Topical Area: Dietary Bioactive Components

Location: Hall D

Poster Board Number: 300

P08-042 - Anticancer Effects of Commercial Doenjangs in AOM/DSS Induced Colitis-associated Colon Cancer in C57BL/6J Mice

Monday, Jun 11
8:00 AM – 3:00 PM

This study was conducted to investigate the anticancer effects of colorectal cancer in C57BL / 6J mice. In order to confirm the anticancer effect of colorectal cancer on doenjang, the mice were divided into 7 groups, the normal control group (Nor), control group (Con), Miso doenjang from Japan diet group (M-D), Korean traditional doenjang diet group (T-D) Home-made doenjang diet group (H-D), Complex doenjang diet group (C-D) and Korean doenjang diet group (K-D). After the end of the experiment, the length / weight ratio of the colon was measured and the ratio of the C-D and K-D groups was significantly reduced compared to the Con group (p <0.05). The number of tumors in the colon was not significantly different in the M-D, T-D, and H-D groups compared to the Con group, but the numbers of tumers in C-D and K-D groups was significantly reduced (p<0.05).  Histopathologic analysis of the colon revealed that the C-D and K-D groups had recovered intestinal tissue similar to that of the normal control group, compared to the Con group, which had high tumor development and cancer cell infiltration. In case of serum pro-inflammatory cytokines, TNF-α levels were significantly reduced in the C-D and K-D groups than in the Con group, and the IL-1β and IL-6 levels were also significantly reduced in (P<0.05). The mRNA levels of iNOS and COX-2 identified by RT-PCR were significantly reduced in all experimental groups than the Con group (p<0.05). In addition, mRNA expression levels of cyclin D1 were significantly reduced in all experimental groups than in Con group, and caspase-3 and caspase-9 were significantly increased in C-D and K-D groups than Con group (p<0.05). K-D and C-D diet group have higher anticancer effects in the mice induced colon cancer compared to other experimental groups. It seems that the anticancer effect was induced in the traditional meju used in both groups, and considered to be due to materials or manufacturing methods different from other groups.

CoAuthors: Sung-Eun Choi – Hoseo University; Kun-Young Park – Cha University

Soon Ah Kang

Professor
Hoseo University
Seoul, Seoul-t'ukpyolsi, Republic of Korea