Poster Topical Area: Dietary Bioactive Components

Location: Hall D

Poster Board Number: 299

P08-041 - Anti-Hepatitis Effect of Korean Thistle on CCl4 Induced Hepatitis Rat

Monday, Jun 11
8:00 AM – 3:00 PM

We investigated the hepatitis inhibition effect of Korean thistle extracts on rat hepatitis induced by carbon tetrachloride(CCl4). We divided seven groups : Normal(no treatment), Control(added CCl4), C-T-L(CCl4+thistle low conc.), C-T-M(CCl4+thistle medium conc.), C-T-H(CCl4+thistle high conc.), C-AC(CCl4+L-acetyl cystine) and C-S (CCl4+silymarin). The weight of each group and the weight of organs (kidney, spleen, testes) did not show any particular difference. However, liver weight was increased in the CCl4-treated group compared to the normal group. Serum levels of ALT and AST were significantly higher in the control group than in the normal group, but ALT and AST levels in the C-T-H group was significantly lower than control group (P<0.05).  Lactate dehydrogenase (LDH), another liver enzyme, was found to be higher in the control group than in the normal group. LDH levels in the C-T-H group was also significantly lower than control group (P<0.05). In addition, C-T-H group was no significant difference from the positive control group. Serum triglyceride (TG) was higher in the control group than in the normal group, but C-T-H group was significantly lower than control group (P<0.05). Total cholesterol (TC) was also significantly increased in the control group compared to the normal group. In the liver, catalase and superoxide dismutase (SOD) activities were decreased in the CCl4-treated group compared to the normal group, and SOD activity was significantly increased in the C-T-H group compared to the control group (P<0.05).  Therefore, high intake of thistle to rat hepatitis induced by carbon tetrachloride decreases the level of liver enzyme, neutral lipid in serum, and increases SOD activity in liver. This suggests that the antioxidant effect of thistle suppresses the inflammatory response in the liver, and the thistle high concentration group has a similar effect to the positive control, which is considered to be effective for antioxidant and hepatitis suppression of thistle.

CoAuthors: Ji-Hae Kim – Hoseo University; Kun-Young Park – Cha Univerisity

Soon Ah Kang

Professor
Hoseo University
Seoul, Seoul-t'ukpyolsi, Republic of Korea