Poster Topical Area: Energy and Macronutrient Metabolism
Location: Hall D
Poster Board Number: 460
High fat and high fructose (HFHF) diet is known to cause metabolic syndrome in animals. As the intakes of the HFHF diet increases, the incidence of chronic diseases such as obesity, metabolic syndrome (MetS) and type 2 diabetes mellitus increases. The aim of this study was to investigate the effects of dietary dried chokeberry powder in the HFHF diet induced metabolic disorder mice model.
After a week of adaptation period, the 6-week-old male C57BL/6J mice were randomly divided into 3 groups (n=7 for each group) of the normal diet group (ND), the HFHF diet group (HF), and the HFHF diet with 1% chokeberry group (CH). Animals in each group were fed with corresponding diets for 10 weeks. Body weight gain of each group for 10 weeks was 6.38±1.66g in ND group, 17.99±2.87g in HF group, and 9.84±2.52g in CH group, respectively. Liver weight in the HF group(1.18±0.10g) was significantly higher than in the ND group(0.96±0.10g), and liver weight of CH group was decreased compared with the HF group (p=0.0003). Abdominal fat weights in CH group was lower than that of the HF group (p<0.0001), and also epididymal fat weights in the CH groups was shown significnat decrease than that of the HF group (p<0.0001). There were significant decreases in serum insulin level and HOMA-IR (Homeostatic model assessment) (p=0.0006, p=0.0003). Moreover, fasting blood glucose level of end point decreased in CH group compared to the HF group (p=0.0222). Serum triglyceride and total cholesterol concentration decreased in chokeberry fed groups compared to the HF group (p<0.0001). The concentrations of serum cholesterols changed with the intake of chokeberry. In the CH group, HDL cholesterol tended to decrease than the HF group (p=0.0707). However, LDL, VLDL, and non HDL cholesterols were significantly decreased compared with the HF group (p<0.0001). As a result of OGTTs, the CH group shown decreased blood glucose level at 90min and 120min than the HF group without a significant difference. Hepatic SOD2, and GPx expression did not changed among all groups (p=0.3295, p=0.2153).
Conclusively, these results might suggest that dietary chokeberry powder supplementation may exert protective effects by improving the serum lipid concentration with controlling of insulin resistance on the HFHF diet induced metabolic disorder mice.
Sookmyung Women's University
Seoul, Seoul-t'ukpyolsi, Republic of Korea