Poster Topical Area: Nutrient-Gene Interactions

Location: Hall D

Poster Board Number: 450

P17-027 - Coffee Consumption and Genetic Risk Score in Blood Pressure: Gene-Diet Interaction Analysis in a Population-Based Study

Sunday, Jun 10
8:00 AM – 6:00 PM

Objective: This study aimed to investigate the interaction between usual coffee consumption and a genetic risk score related to high blood pressure, in a representative sample of São Paulo population.
Methods:
Data came from the "Health Survey of Sao Paulo (ISA-Capital)", a population-based and cross-sectional household health survey. The study sample included 533 participants aged 20 years or older, living in São Paulo city, Brazil. Coffee consumption was assessed by two 24-hour dietary recalls and categorized into <1, 1-3, and >3 cups/day . The unweighted genetic risk score (GRS) was calculated using four single nucleotide polymorphisms (SNPs) [CYP1A1/CYP1A2 (rs2470893, rs2472297); CPLX3/ULK3 (rs6495122); MTHFR (rs17367504)] described in previous genome-wide association studies (GWAS). Multiple logistic regression analysis were performed to estimate adjusted odds ratio (OR) and 95% confidence intervals (CI) for associations between high BP, and both, high systolic BP (SBP) and diastolic (DBP) with the GRS. Thereafter, the effect of interaction between the GRS and coffee consumption on high BP, SBP and DBP was tested by including the respective multiplicative interaction term in the logistic regression models.
Results:
All polymorphisms were in Hardy-Weinberg equilibrium. After adjustment for potential confounding factors, the findings suggested that higher GRS independently contributed to higher probability of elevated BP, SBP and DBP in this population (OR=1.85, 95%CI=1.19-2.87; OR=2.30, 95%CI=1.32-4.01 and OR=1.66, 95%CI=1.10-2.51; respectively). Moreover, there was a significant interaction effect for coffee consumption and GRS on the high BP, and both SBP and DBP. A single point rise in the GRS increases the probability of high BP (OR= 5.09, 95% CI= 1.32-19.7) and both elevated SBP and DBP (OR=2.14, 95%CI=1.12-4.11; OR=3.54, 95%CI=1.17-10.75), among participants with high coffee consumption (>3 cups coffee/day).
Conclusions:
Consumption of coffee could interact with genetic predisposition in relation to BP. Thus, individuals with greater GRS appeared to have high BP associated with higher coffee consumption, highlighting the particular importance of reducing coffee intake in individuals genetically predisposed to this CVD risk factor.




Funding Source: Financial support from Sao Paulo Research Foundation (FAPESP) (grant number 2014/04540-2), and from National Counsel of Technological and Scientific Development (CNPq) (procedurals 481176/2008-0, 473100/2009-6, and grant number 306029/2011-1).

CoAuthors: Josiane Steluti – School of Public Health, University of Sao Paulo; Marina Norde – School of Public Health, University of Sao Paulo; Regina Fisberg – School of Public Health, University of Sao Paulo; Dirce Marchioni – School of Public Health, University of Sao Paulo

Andreia M. Miranda

PhD
School of Public Health, University of Sao Paulo
São Paulo, Sao Paulo, Brazil