Poster Topical Area: Aging and Chronic Disease

Location: Auditorium

Poster Board Number: 111

P01-092 - Dietary intake of B vitamins in midlife and cognitive impairment in old age: The Singapore Chinese Health Study

Sunday, Jun 10
8:00 AM – 6:00 PM

Objective: Few studies have examined the association between dietary intake of B vitamins and cognitive function in Asian population. We investigated the relation of dietary intakes of thiamin (B1), riboflavin (B2), niacin (B3), vitamin B-6 (pyridoxine), folate (B9) and vitamin B-12 (cobalamin) in midlife with cognitive impairment in old age in a Chinese population.


Method:
This study included 16,948 participants from the Singapore Chinese Health Study, a population-based prospective cohort, who were 43-74 years at baseline (1993-1998) and 61-96 years at follow-up 3 (2014-2016). We computed intake of B vitamins at baseline using a validated 165-item food frequency questionnaire and the Singapore Food Composition Database. We used the Mini-Mental State Examination (MMSE) scale to measure cognition at follow-up 3, and defined cognitive impairment using education-specific cut-offs. We used logistic regression models to estimate odds ratios (ORs) and 95% confidence intervals (CIs) of cognitive impairment risk, and general linear models to calculate the adjusted MMSE scores.


Results:
A
total of 2,443 participants had cognitive impairment. In multivariable logistic regression analysis that included lifestyle, medical history and dietary pattern scores, intakes of thiamine, niacin, folate and riboflavin were associated with risk of cognitive impairment. However, in the final model that included mutual adjustment of B vitamins, only the associations of folate and riboflavin remained significant: the OR (95% CI) comparing the highest with the lowest quartile was 0.83 (0.70, 0.98) for folate, and 0.82 (0.69, 0.97) for riboflavin (both P-trend<0.05). The adjusted mean difference of MMSE scores also increased significantly in a dose-dependent manner with higher quartile intake of folate and riboflavin (both P-trend <0.003). The mean differences in MMSE scores comparing extreme quartiles for intake of riboflavin and folate were equivalent to the differences in scores comparing age difference of 1.67 and 1.72 years, respectively. Intakes of thiamin, niacin, vitamin B-6 and vitamin B-12 were not associated with risk of cognitive impairment.


Conclusion:
Higher dietary intakes of riboflavin and folate in midlife could be associated with a lower risk of developing cognitive impairment in old age.



Funding Source:

The study was supported by grants from the National Medical Research Council, Singapore (NMRC/CSA/0055/2013), and the NIH (grants R01 CA144034 and UM1 CA182876). An Pan is supported by the National Key Research and Development Program of China (2017YFC0907504).


Multivariable-adjusted odds ratios for cognitive impairment according to quartile of dietary intakes of B vitamins

CoAuthors: Yi-Wen Jiang – School of Public Health, Tongji Medical College, Huazhong University of Science and Technology; An Pan – School of Public Health, Tongji Medical College, Huazhong University of Science and Technology; Woon-Puay Koh – Duke-NUS Medical School, Singapore

Li-Ting Sheng

graduate student
Department of Epidemiology and Biostatistics, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology
Wuhan, Hubei, China (People's Republic)