Poster Topical Area: Dietary Bioactive Components

Location: Hall D

Poster Board Number: 263

P08-005 - Effect of green tea extract on oxidative stress and renal function in diabetic individuals: a randomized, double-blinded, controlled trial

Monday, Jun 11
8:00 AM – 3:00 PM

BACKGROUND/OBJECTIVES: The effect of green tea on oxidative stress and renal function in diabetic patients remains inconclusive, thereby making its assessment relevant as an additional therapy for attenuation and prevention of renal disease in this population. Thus, this study aimed to evaluate the effect of green tea extract on oxidative stress and renal function in diabetic individuals.

SUBJECTS/METHODS: A randomized, double-blinded, controlled clinical trial was developed with 60 diabetic individuals. Patients were assigned to two equal groups to receive green tea extract (n=30, two capsules/day, containing 560 mg of polyphenols each) or cellulose (n=30, two capsules/day) for 20 weeks. Blood glucose, glycosylated hemoglobin, insulin, antioxidant enzymes, total antioxidant capacity, serum creatinine, urea, glomerular filtration rate and albuminuria were analyzed.

RESULTS: No significant difference was observed in glycemic control, renal function or oxidative stress, except for superoxide dismutase. After 20 weeks, green tea extract maintained this enzyme activity (14.29 ± 5.00 U/mg of protein at baseline and 12.51 ± 7.39 U/mg of protein at 20 weeks), whereas an expressive reduction in the placebo group was noted (13.71 ±5.83 U/mg of protein at baseline and 8.53 ± 3,54U/mg of protein at 20 weeks), with a higher superoxide dismutase activity in the green tea group after intervention (p=0.014).

CONCLUSION: Green tea extract prevented the reduction of superoxide dismutase activity, however it was not associated with an improvement in total antioxidant capacity, glycemic control markers or renal function in diabetic individuals after 20 weeks of supplementation.




Funding Source: This research received no specific grant from any funding agency, or commercial or not-for-profit sectors.

CoAuthors: Sáskia Vaz – Faculty of Nutrition, Federal University of Goiás, Brazil; Luiza Amorim – Faculty of Nutrition, Federal University of Goiás, Brazil; Pamella Nascimento – Pontifical Catholic University of Goiás, Brazil; Valéria Veloso – Service of Nephrology, Department of Internal Medicine, Federal University of Goiás, Brazil; Marina Nogueira – Functional Food Development Laboratory, University of São Paulo, Brazil; Inar Castro – Functional Food Development Laboratory, University of São Paulo, Brazil

Patrícia BORGES.. Botelho

Professor
Faculty of Nutrition, Brasília University, Brazil
Brasília, Goias, Brazil