Poster Topical Area: Nutrient-Gene Interactions

Location: Hall D

Poster Board Number: 445

P17-022 - Genetic Variation of Lean Body Mass and Weight Loss in Response to Diet Interventions: the POUNDS Lost Trial

Sunday, Jun 10
8:00 AM – 6:00 PM

Abstract

Background: A recent genome-wide association study identified genetic variants determining lean body mass; however, little has been clarified whether these genetic variants affect weight loss in response to dietary interventions.

Objective:

We examined whether a genetic risk score (GRS) determining lean body mass was associated with diet-induced weight-loss and the changes in appetite measures.

Method:

This study included 692 overweight and obese adults who were randomly assigned to 1 of 4 diets varying in macronutrient intake in Preventing Overweight Using Novel Dietary Strategies trial (POUNDS Lost). A GRS was calculated based on 5 single nucleotide polymorphisms (SNPs) associated with lean body mass. An overall appetite score was calculated including measures of cravings, fullness, prospective consumption, and hunger. We investigated relations between the GRS and 6-month changes in body weight, waist circumference, and the appetite measures.

Result:

We found that the dietary fat intake (low v.s. high) significantly interacted with the lean body mass GRS on changes in body weight, waist circumference, and the appetite measures from baseline to 6 months (P for interaction was 0.015, 0.024, and


Conclusions:


Our findings suggest that genetic variation of lean body mass may differentially affect adiposity changes according to dietary fat intakes, probably through the varied genetic effect on appetite.

Trial registration:

ClinicalTrials.gov NCT00072995.



KEYWORDS Lean body mass, Genetic risk score, Gene-diet interaction



Funding Source:

The study was supported by grants from the National Heart, Lung, and Blood Institute (HL071981, HL034594, HL126024), the National Institute of Diabetes and Digestive and Kidney Diseases (DK115679, DK091718, DK100383, DK078616), the Boston Obesity Nutrition Research Center (DK46200), and United States – Israel Binational Science Foundation Grant2011036. Dr. Qi was a recipient of the American Heart Association Scientist Development Award (0730094N).


CoAuthors: Dianjianyi Sun – Tulane University School of Public Health and Tropical Medicine; Tao Zhou – Tulane University School of Public Health and Tropical Medicine; Yoriko Heianza – Tulane University School of Public Health and Tropical Medicine; George Bray – Pennington Biomedical Research Center, Louisiana State University; Frank Sacks – Harvard T.H. Chan School of Public Health; Lu Qi – Tulane University School of Public Health and Tropical Medicine

Xiang Li

Graduate student
Tulane University School of Public Health and Tropical Medicine
New Orleans, Louisiana