Poster Topical Area: Medical Nutrition

Location: Hall D

Poster Board Number: 655

P14-031 - A Branched-Chain Amino Acid Supplement Enriched with Isoleucine Improves Glucose and Insulin Sensitivity in College-Age Males but not in Females

Monday, Jun 11
8:00 AM – 3:00 PM

Objective: The purpose of this study was to examine how branched-chain amino acid BCAAs enriched with isoleucine would influence glucose tolerance following meal compared to the standard ratio of 2:1:1 (leucine:isoleucine:valine).
Methods: We recruited healthy male (n=13) and female (n=5) participants and subjects were asked to fast for 12 hours before a fasting blood collection. Subjects then consumed of a breakfast containing 113 g carbohydrates, 8 g protein, 1.5 g fat and BCAA powder in the 2:1:1 ratio (Control) or BCAA powder enriched with Isoleucine (2:6:1) added to orange juice. We collected blood samples at 30, 60, 90, and 120 minutes' post meal.
Results: No differences were observed for changes in serum glucose or insulin response between the Control and Isoleucine when examining all subjects together. However, when comparing each gender, males had significantly lower serum glucose with Isoleucine at 60 and 90 minutes compared to Control; while females had significantly higher serum glucose with Isoleucine at 30 and 90 minutes compared to Control. Also, males with Isoleucine had significantly lower serum glucose at 90 minutes and insulin at all-time points compared to females with Isoleucine.
Conclusion: Our study indicates a significant difference in the way genders respond to BCAA supplementation where isoleucine may improve glucose tolerance and insulin response in men but not females.




Funding Source: University of Massachusetts Lowell Seed Grant

CoAuthors: Michael Dellogono – University of Massachusetts Lowell; Lyra Clark – University of Massachusetts Lowell

Thomas A. Wilson

Associate Professor
University of Massachusetts Lowell
Lowell, Massachusetts