Poster Topical Area: Biomarkers
Poster Board Number: 143
Objective: Nutritional status may play a role in affecting the progression of diabetes. It is, therefore, important to characterize diabetes sub-phenotypes based on nutritional biomarkers and evaluate their associations with all-cause mortality.
Methods: Nationally representative sample in the NHANES III (The Third National Health and Nutrition Examination Survey, 1988-1994) with morality follow-up data obtained through 2000 were utilized to explore possible sub-phenotypes of diabetes determined based on tertile levels of 28 nutritional biomarkers. Weighted logistic regression analyses were performed among 2,130 diabetic patients aged 20 to 90 years with adjustment for age, sex, race, BMI, smoking status, drinking status, physical activity, and educational background.
Results: An increased risk of all-cause mortality associated with urine albumin (P for trend<.0001) was observed. In contrast, higher levels of serum sodium (P for trend=.01) and alpha carotene (P for trend=.003) were associated with a decreased risk of all-cause mortality. It would be necessary to report the results in sensitivity analyses (either controlling renal function or composite comorbid conditions). In addition, these significant associations were not modified by age, sex, and race.
Conclusions: In conclusion, our results indicate that some nutritional biomarkers are reliable predictors of diabetes-related mortality and have potential clinical values for improving risk stratification in diabetic patients, though further validation of their respective and joint predictive values is needed.
Indiana University Richard M. Fairbanks School of Public Health