Poster Topical Area: Dietary Bioactive Components
Location: Hall D
Poster Board Number: 378
Objectives: Microbial fermentation mainly characterised by Eurotium cristatum is involved in the processing of dark tea, a tranditional Chinese tea widely used from the Ming Dynasty at 1500 A.D., which has received increasing attention in recent years owing to its benefits, especially anti-obesity and hypolipidemic effects, to human health.
Methods: High-fat diet induced rat model 50 male SD rats were randomly divided into 5 groups fed with normal or 60% high-fat diet, given distilled water or the Eurotium cristatum fermented Dark Tea Extractby intragastric administration for 9 weeks. Blood lipid was tested at baseline(1st week) and endpoint(9th week), and body fat ratio was calculated from perirenal & epididymal fat weight at endpoint. Body weight, food intake and energy intake was weekly recorded. Differential expressed genes of rat liver were analyed using gene microarray and real-time RT-PCR.
Results: Body weight, serum triglycerides, food intake and energy intake of 250 mg/kg BW & 750mg/kg BW Eurotium cristatum fermented Dark Tea Extract group were significantly decreased forhigh-fat diet induced rat model. Gene microarray and realtime RT-PCR revealed changed PPAR signaling pathway might be a potent mechanism for decreased body weight and serum triglycides.
Conclusion: The Eurotium cristatum fermented Dark Tea Extract decreases body weight and serum triglycerides for SD rats.
COFCO Nutrition and Health Research Institute
Beijing, Beijing, China (People's Republic)