Poster Topical Area: Dietary Bioactive Components

Location: Hall D

Poster Board Number: 378

P08-120 - Effect of Eurotium cristatum fermented Dark Tea Extract on body weight and blood lipid in rats

Monday, Jun 11
8:00 AM – 3:00 PM

Objectives: Microbial fermentation mainly characterised by Eurotium cristatum is involved in the processing of dark tea, a tranditional Chinese tea widely used from the Ming Dynasty at 1500 A.D., which has received increasing attention in recent years owing to its benefits, especially anti-obesity and hypolipidemic effects, to human health.

Methods: High-fat diet induced rat model 50 male SD rats were randomly divided into 5 groups fed with normal or 60% high-fat diet, given distilled water or the Eurotium cristatum fermented Dark Tea Extractby intragastric administration for 9 weeks. Blood lipid was tested at baseline(1st week) and endpoint(9th week), and body fat ratio was calculated from perirenal & epididymal fat weight at endpoint. Body weight, food intake and energy intake was weekly recorded. Differential expressed genes of rat liver were analyed using gene microarray and real-time RT-PCR.

Results: Body weight, serum triglycerides, food intake and energy intake of 250 mg/kg BW & 750mg/kg BW Eurotium cristatum fermented Dark Tea Extract group were significantly decreased forhigh-fat diet induced rat model. Gene microarray and realtime RT-PCR revealed changed PPAR signaling pathway might be a potent mechanism for decreased body weight and serum triglycides.

Conclusion: The Eurotium cristatum fermented Dark Tea Extract decreases body weight and serum triglycerides for SD rats.



Funding Source: This research is financially supported by the Beijing Municipal Science and Technology Project (Grant No. Z161100000616012), CHINA Key R & D Project (2016YFD0400602) and China National Native Produce & Animal By-products Imp. & Exp. Corp., a wholly-owned subsidiary of COFCO.

CoAuthors: Ting Liu – COFCO Nutrition and Health Research Institute

Liming Wang

Senior Scientist
COFCO Nutrition and Health Research Institute
Beijing, Beijing, China (People's Republic)