Poster Topical Area: Vitamins and Minerals
Location: Hall D
Poster Board Number: 508
Objectives: Oxidative stress, defined as excess reactive oxygen species production with diminished antioxidant substances, can cause widespread effects in type 2 diabetes mellitus (T2D) and chronic kidney disease (CKD).Oxidative balance score (OBS) involves measuring exogenous dietary factors associated with antioxidant and pro-oxidant properties. In cultured cells and animals, RAGE increases oxidative stress. Although higher levels of sRAGE are associated with lower cellular stress, in CKD, levels of sRAGE rise. Here, we assess whether dietary OBS in patients with T2D and mild CKD is associated with disease state characteristics.
Methods: Utilizing baseline 3-day diet diary assessments from the Healthy Hearts and Kidneys (HHK) study, OBS was calculated by analyzing 11 a priori-defined factors: β-cryptoxanthine, alcohol, polyunsaturated fatty acids, iron, vitamin C, α-carotene, β-carotene, vitamin E, total tocopherol, lutein (combined with zeaxanthin), and lycopene. A higher OBS score indicates more antioxidant and less pro-oxidant intake. The sample was dichotomized based on the median (OBS<11 and OBS≥11). Disease state characteristics were defined as baseline levels of soluble form of the receptor for advanced glycation end products (sRAGE), endogenous secretory receptor (esRAGE), estimated glomerular filtration rate (eGFR), hemoglobin A1c (HbA1c), and albuminuria (24-hour). Independent sample t-tests were performed using OBS as the independent variable and disease state characteristics as dependent variables.
Results: The sample (n=88) had a mean HbA1c of 7.5% and mean eGFR of 70.7 mL/min/1.73 m2. There were no statistically significant associations between OBS and esRAGE, sRAGE, HbA1c, eGFR, and albuminuria. However, those with OBS≥11 tended towards having higher sRAGE (1043.2 pg/ml vs. 892.3 pg/ml; p=0.195), higher HbA1c (7.68% vs. 7.32%; p=0.275), higher albuminuria (169 vs. 56.1; p0.095), and lower eGFR (67.4 vs. 74.6; p=0.199).
Conclusion: Subjects with higher OBS trended toward higher sRAGE levels and more severe disease state measures in both T2D and CKD.Further studies are required to determine the role of dietary oxidative balance in the development and progression of diabetic CKD.
This research was supported by NIH-R01-DK100492 and the NYU Langone Medical Center Intramural Fund.
New York University
Hoboken, New Jersey