Poster Topical Area: Vitamins and Minerals

Location: Hall D

Poster Board Number: 507

P26-046 - Demographic Factors Associated with Dietary Oxidative Balance Score in Patients with Type 2 Diabetes and Concurrent Kidney Disease

Sunday, Jun 10
8:00 AM – 6:00 PM

Objectives: Atherosclerotic complications of Type 2 diabetes mellitus (T2D) have been linked to oxidative stress and appear to be modifiable with a diet high in natural antioxidants. Oxidative balance score (OBS) is an estimate of a subject's overall pro- and antioxidant exposure status assessed from daily dietary intake records. Prior research shows OBS in a cancer patient population to be associated with age, race, gender, education, and income. In this report, we characterize the OBS of individuals with T2D and concurrent chronic kidney disease (CKD) and explore demographic covariates of this measure.
We utilized 3-day dietary diary assessments collected at baseline from participants in the Healthy Hearts and Kidneys (HHK) study. OBS was calculated by analyzing 11 a priori-defined factors: β-cryptoxanthine, alcohol, polyunsaturated fatty acids, iron, vitamin C, α-carotene, β-carotene, vitamin E, total tocopherol, lutein (combined with zeaxanthin), and lycopene. A higher OBS score indicated more antioxidant and less pro-oxidant intake. Race, sex, education level, employment, and marital status were assessed through baseline questionnaires. Participants also were asked whether their current household income meets their basic needs. Independent sample t-tests were performed to test hypotheses.
The sample (n=88) was white (78.4%), male (62.5%), married or living as married (57.5%), and employed (60%) with a mean age of 66.3 years. There were no significant differences in OBS due to race (white vs. non-white), sex, marital status, employment, or education level. 88.6% of the participants reported that their current household income met their basic needs; those who reported adequate income had significantly higher mean OBS than those who did not (p=0.01).
Prior research shows OBS to be associated with age, race, sex, education, and income. In a narrowly defined sample of individuals with T2D and concurrent CKD, OBS was associated only with income. Counseling regarding the intake of foods high in natural antioxidants should consider subject income status. Due to the cross-sectional nature of the data and the small homogeneous sample drawn from a single geographic region, caution must be used in drawing firm conclusions from this report.

Funding Source: This research was supported by NIH-R01-DK100492 and the NYU Langone Medical Center Intramural Fund.

CoAuthors: Blake Mergler – New York University; Ram Jagannathan – New York University; Kathleen Woolf – NYU School of Culture, Education, and Human Development; Mary Ann Sevick – New York University

Collin Popp

Post-doctoral Fellow
New York University
Hoboken, New Jersey