Poster Topical Area: Vitamins and Minerals

Location: Hall D

Poster Board Number: 477

P26-015 - Dietary intakes of fat soluble vitamins and risk of type 2 diabetes mellitus

Sunday, Jun 10
8:00 AM – 6:00 PM

Objective: Although the main pathology in Type 2 diabetes mellitus (T2DM) is linked to the metabolism of energy and macronutrients; however, recent studies have shown that micronutrients are also involved. Micronutrients with antioxidant effects; such as vitamin A and E may have protective effects; moreover, interests in possible roles of vitamin K and D have also been shown. However, a few reports have investigated the association between the dietary vitamin intakes and the risk of T2DM. Therefore, we examined our hypothesis that higher dietary intakes of fat-soluble vitamins A, K E, and D may be associated with the reduced risk of T2DM in Japanese population.


Methods:
A prospective study encompassing 19,168 healthy Japanese men and women aged 40-79 years in whom the associations between dietary intakes of fat soluble vitamins -determined by a validated self-administered food frequency questionnaire- with risk of 5-year cumulative incidence of validated physician-diagnosed T2DM, were evaluated by the logistic regression model.


Results:
We ascertained 494 self-reported new cases of diabetes within 5-year period. Increasing dietary intakes of vitamin K and E were associated with the reduced risk of incident T2DM; whereas, no associations with dietary intakes of vitamin A or D were seen. The multivariable OR (95% CI) in the highest versus the lowest quartile of intakes were 0.73 (0.55 - 0.97; P-trend = 0.02) for vitamin K and 0.68 (0.49 - 0.94; P-trend = 0.02) for vitamin E. The observed inverse associations with dietary vitamin K was more robust among younger, females, and non-smoker subjects more than older, males, and current smoker subjects, respectively; however, the P for interactions with these variables did not reach a level of significance, P were >0.10.

Conclusions: Higher dietary intakes of fat soluble vitamins K and E, but not vitamins A or D were associated with the reduced risk of T2DM among Japanese population.



Funding Source:

This study was supported by Grants-in-Aid for Scientific Research from the Ministry of Education, Science, Sports and Culture of Japan (61010076, 62010074, 63010074, 1010068, 2151065, 3151064, 4151063, 5151069, 6279102, 11181101, 17015022, 18014011, 20014026, and 20390156); and Comprehensive Research on Cardiovascular and Lifestyle Related Diseases (H26-Junkankitou [Seisaku]-Ippan-001).



CoAuthors: Hiroyasu Iso, MD, MPH, PhD – Osaka University; Akiko Tamakoshi, MD, PhD – Hokkaido University

Ehab S. Eshak

Lecturer
Minia University, Egypt and Osaka University, Japan
Suita Shi, Osaka, Japan