Poster Topical Area: Obesity

Location: Hall D

Poster Board Number: 646

P23-019 - Functional rare sugar can improve the inflammatory index in diet induced obese mice with alteration of microbiome profile

Sunday, Jun 10
8:00 AM – 6:00 PM

Objectives: Recently there has been a global shift in diet towards increased intake of energy-dense foods that are high in sugars. Functional rare sugar(FRS) which is sweet, but has no calorie, have received attention as a sugar substitute. The FRS has been reported as one of anti-inflammatory food components, however, its mechanism is not yet completely understood.

Methods: Forty C57BL/6J mice were dived in to 4 dietary groups and fed a normal diet (ND), a High-fat diet (HFD, 20% fat, 1% cholesterol, w/w), HFD with 5% erythritol(ERY) and FRS supplement for 16 weeks. A pair-feeding approach was used so that all groups receiving the high fat diet would have the same calorie intake.

Results: In our study body weight and body fat mass in FRS group were significantly decreased toward level of normal group with a simultaneous decrease in plasma leptin and resistin and plasma leptin:adiponectin ratio. Fecal short-chain fatty acid(SCFA) production analysis revealed that functional rare sugar induced elevated total SCFA production compared to other groups. Also, amount of acetate, propionate and butyrate production was significantly increased in functional rare sugar group. The FRS supplement increased Lactobacillus, Coprococcus and Allobaculum that could be responsible for improving the inflammation based on pyrosequencing analysis and FRS significantly decreased the inflammatory cytokines levels such as TNF-α, Interferon-𝛄, Interleukin 1-β and Interleukin 6 in plasma.

Conclusions: Taken together, our findings suggest that 5% dietary FRS led to improvement of HFD- induced inflammation by altering microbiome community.




Funding Source:

This study was supported by the National Research Foundation of Korea(NRF) grant, funded by the Korea government (NRF-2016R1A2B4011329), the Science Research Center project (NRF-2015R1A5A6001906) and the Bio-Synergy Research Project (NRF-2012M3A9C4048818) of the Ministry of Science, ICT and Future Planning through the National Research Foundation.

CoAuthors: Youngji Han – Kyungpook National University; Jiwon Kim – Kyungpook National University; Eun Jeong Do – Kyungpook Nationl University; Dayoun Lee – Kyungpook National University; Eun-Young Kwon – Kyungpook National University; Yong Bok Park – Kyungpook National University

Myung-Sook Choi

Professor
Kyungpook National University
Daegu, Taegu-jikhalsi, Republic of Korea