Poster Topical Area: Dietary Bioactive Components

Location: Hall D

Poster Board Number: 297

P08-039 - Ginger exerts anti-arthritic effect by modulating inflammatory cytokine levels in collagen-induced arthritis : An In vivo Model

Monday, Jun 11
8:00 AM – 3:00 PM

Rheumatoid arthritis is a chronic autoimmune disease considered by an increased synovial inflammatory response due to destruction or erosion of articular cartilage in major joints. Ginger extract, high potency ginger has 30% bio actives and a minimum of 25% gingerols, has antioxidant and anti-inflammatory properties. The aim of this study was to investigate the effect of ginger extract on oxidative stress and inflammatory responses in a collagen-induced rheumatoid arthritis rat model (CIA). Female Wistar rats (n=7; 8 week-old; 180±20) treated as follows: (i) Group I rats treated with saline served as a control, (ii) Group II rats subjected to CIA induction by intra-dermal injection of bovine collagen II type served as the induced group, (iii) Group III rats induced with CIA and administered with 50 mg/kg BW ginger extract (GingeverTM) for 33 days. Decreased arthritic scores, decreased serum levels of interleukin 6 (IL-6), interleukin 17 (IL-17), tumor necrosis factor alpha (TNF-α), and dickkopf-related protein 1 (DKK-1) and increased serum obestatin and sclerostin levels observed in Group III treated animals. Group III administration reduced the levels of TNF-α, IL-17, nuclear factor kappa B (NF-kB), and cyclooxygenase 2 (COX-2) proteins levels in joint tissues. A significant decrease in inflammation and destruction scores observed in Group III compared with Group II treatment. In conclusion, the results of this study show that ginger extract treatment (Group III) may affect the inflammatory cascade in CIA-induced rats and may show anti-rheumatoid arthritis properties.


Funding Source: OmniActive Health Technologies Ltd. India

CoAuthors: Cemal Orhan, Ph.D – Firat University; Mehmet Tuzcu Tuzcu, Ph.D – Firat University; Nurhan Sahin, Ph.D – Firat University; Suleyman Koca, MD – Firat University; Kazim Sahin, DVM, Ph.D – Firat University

Vijaya Juturu

Director (Global) Clinical Affairs
OmniActive Health Technologies Inc.
Morristown, New Jersey