Poster Topical Area: Aging and Chronic Disease

Location: Auditorium

Poster Board Number: 55

P01-036 - Coffee consumption and liver-related hospitalizations and deaths in the ARIC study

Sunday, Jun 10
8:00 AM – 6:00 PM

Objective: Coffee is one of the most frequently consumed beverages in the world. Consumption of coffee is associated with reduced risk of all-cause mortality, as well as specific causes of mortality such as liver disease. However, few studies have examined the association between coffee and hospitalizations or deaths related to the liver. The objective is to evaluate the association between coffee consumption and risk of liver-related hospitalizations and deaths.


Methods:
We conducted a prospective analysis on 14,208 participants from the Atherosclerosis Risk in Communities (ARIC) study aged 45-64 years. Coffee consumption (cups/day) was assessed using food frequency questionnaires at visit 1 (1987-89) and visit 3 (1993-95). Liver-related hospitalizations were defined as a hospitalization with any International Classification of Diseases, Ninth Revision (ICD-9) code related to liver disease identified through cohort surveillance. Liver-related death was defined as any death with a liver disease ICD-9 code listed anywhere on the death certificate form.


Results:
There were 833 incident cases of liver-related hospitalizations over a median follow-up of 24 years and 238 liver-related deaths over a median follow-up of 26 years. The average amount of coffee consumed was 1.7 8-ounce cups per day. Participants who were male, white, current smokers, and current alcohol drinkers were more likely to drink higher amounts of coffee per day. After adjusting for demographic, clinical, and dietary factors, consuming ≥3 cups/day of coffee was significantly associated with a reduced risk of liver-related hospitalizations compared with never drinkers (hazard ratio: 0.79, 95% CI: 0.63-0.99). There were no significant associations between coffee consumption and liver-related deaths after adjusting for covariates (hazard ratio for ≥3 cups/day vs. never: 0.80, 95% CI: 0.46-1.37).


Conclusions:
Coffee drinkers may be at a lower risk for liver disease. This supports current evidence that low and moderate levels of coffee may not be harmful to the liver.



Funding Source:

Ms. Hu is supported by a grant from the National Institutes of Health (NIH)/National Heart, Lung, and Blood Institute (training grant T32 HL007024). Dr. Rebholz is supported by a mentored research scientist development award from the National Institute of Diabetes and Digestive and Kidney Diseases (K01 DK107782). Dr. Selvin was supported by NIH/NIDDK grants K24DK106414 and R01DK089174. The Atherosclerosis Risk in Communities study has been funded by the National Heart, Lung, and Blood Institute, National Institutes of Health, Department of Health and Human Services (HHSN268201700001I, HHSN268201700003I, HHSN268201700005I, HHSN268201700004I, HHSN2682017000021).


CoAuthors: Mariana Lazo, MD, PhD – Johns Hopkins Bloomberg School of Public Health; Elizabeth Selvin, PhD, MPH – Johns Hopkins Bloomberg School of Public Health; James Hamilton, MD – Johns Hopkins University School of Medicine; Morgan Grams, MD, PhD, MHS – Johns Hopkins Bloomberg School of Public Health; Lyn Steffen, PhD, MPH, RD – University of Minnesota School of Public Health; Josef Coresh, MD, PhD, MHS – Johns Hopkins Bloomberg School of Public Health; Casey Rebholz, PhD, MS, MPH – Johns Hopkins Bloomberg School of Public Health

Emily Hu

PhD student
Johns Hopkins Bloomberg School of Public Health
Baltimore, Maryland