Oncology - Prostate
Introduction & Objective : Prostate cancer typically has a low rate of prevalence of lethal disease. However, patients who develop prostate cancer at an earlier age may be at risk for a greater risk of dying due to prostate cancer, as life expectancy is greater and younger age of onset is associated with more aggressive disease. Understanding risk of death from prostate cancer by age may affect treatment decisions. This study attempts to characterize the mortality and cause of death (COD) trends associated with age at diagnosis of prostate cancer.
Methods : The relationship between COD and age at diagnosis was investigated using data obtained from the US Surveillance, Epidemiology, and End Results Program (1973-2014) for prostate cancer (N = 1,210,922). Patients in which the cancer was not their primary cancer, COD data was missing, and those with incomplete survival months were excluded. In patients who had known COD, the percent COD due to prostate cancer versus other COD was examined.
Results : A total of 803,331 men were examined. The median follow-up was 74 months. Figure 1 demonstrates the proportion of COD attributable to prostate cancer from age 40-85+. Notably, the percent COD attributed to prostate cancer peaks in the 40-44 year age group at 69%, then gradually decreases until it nadirs in the 75-79 year old age group where it was 24% (p<0.0001).
Conclusions : In the United States, men who were diagnosed at a younger age with prostate cancer were more likely to have their death attributed to prostate cancer than men diagnosed at an older age.