Moderator :
Purna C. Kashyap, MBBS

Assistant Professor of Medicine, College of Medicine and Science
Center for Individualized Medicine
Mayo Clinic
Rochester, Minnesota

Purna Kashyap, MBBS is an Associate Professor of Medicine, Physiology and Biomedical Engineering. He is the Associate Program Director of the Microbiome program at Mayo Clinic, Rochester, MN. Dr. Kashyap’s Gut Microbiome Laboratory is interested in understanding mechanisms by which gut microbes influence health and disease. The human gastrointestinal tract harbors trillions of microbes that live in harmony with their human host and perform processes vital for health. Deleterious alterations in gut microbiota have been associated with a number of disease states such as Clostridium difficile colitis, diseases associated with changes in gastrointestinal function such as irritable bow el syndrome, and metabolic diseases such as obesity. However, the functional role of gut microbes in the development of these diseases remains largely unknown. Dr. Kashyap's laboratory aims to elucidate the complex interactions between diet, gut microbes, and gastrointestinal function. To pursue these objectives, they integrate data generated from multi-omic platforms with in vivo and in vitro physiological measurements from human research participants and gnotobiotic mouse models. These data allow the team to understand the interactions among microbiota-derived bioactive molecules and the key regulators of gastrointestinal function. By combining experimental strategies with bioinformatics analysis, Dr. Kashyap's research team hopes to develop novel microbiota-targeted therapies to treat patients with disorders resulting from altered microbiota function.


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