Clinical Genomics Papers of the Year

Thursday, September 13
12:30 PM - 1:30 PM

Plenary Speaker :
Lisa Bastarache, MS

Manager, Application Development/Lead Data Scientist, Biomedical Informatics
Center for Precision Medicine
Vanderbilt University Medical Center

Lisa Bastarache, MS is a scientist in the Center for Precision Medicine and Vanderbilt University Medical Center. After earning a BS in mathematics and a master’s degree studying linguistic anthropology at the University of Chicago, she began working as a natural language processing programmer at Vanderbilt. She has over a decade of experience developing methods and algorithms to exact phenotypes from the electronic health record (EHR), with particular focus on designing phenotypes for use in genetic association studies. Currently, she is developing methods to identify Mendelian disease patterns in the EHR to help interpret rare genetic variants of uncertain significance and characterize the problem of mis- or under-diagnosis in clinical populations.

Presentation(s):

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Plenary Speaker :
Aris Baras, MD, MBA

Vice-Chair, Head
Regeneron Genetics Center
Regeneron

Aris Baras, MD, MBA, is the Vice President of Regeneron Pharmaceuticals and Head of the Regeneron Genetics Center (RGC), one of the largest human genetics programs in the world, spanning large-scale sequencing, informatics, and translational sciences. They use human genetics to advance and guide the development of Regeneron’s pipeline of important new medicines. Dr. Baras has established and leads several foundational genomics collaborations, such as with the Geisinger Health System to sequence at least 250,000 participants, and with the UK Biobank to sequence 500,000 participants. The RGC has produced many high impact discoveries identifying new drug targets (such as HSD17B13 in chronic liver diseases), validating existing development programs (Regeneron’s evinacumab program targeting ANGPTL3, REGN3500 targeting IL33, and many more), and contributing important new gene discoveries and precision medicine strategies. The RGC has sequenced more than 300,000 individuals to date, collaborating with more than 60 institutions around the world, and plans to sequence the genomes of millions of participants across its studies. Previously, Dr. Baras held roles and responsibilities at Regeneron across R&D and business development. Prior to Regeneron, Dr. Baras contributed to other biotechnology ventures and conducted research spanning antibody based therapeutics, cancer research, and nanotechnology applications in drug development. Dr. Baras received his Bachelors of Science, MD, and MBA, all from Duke University.

Presentation(s):

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Plenary Speaker :
Pradeep Natarajan, MD, MMSc

Director
Preventative Cardiology
Massachusetts General Hospital

Pradeep Natarajan, MD MMSc, is Director of Preventive Cardiology at Massachusetts General Hospital, Assistant Professor of Medicine at Harvard Medical School, and Associate Member of the Broad Institute of Harvard and MIT. He received his BA in molecular biology with Honors and Phi Beta Kappa in 2004 from the University of California, Berkeley. He received his MD with Alpha Omega Alpha in 2008 from the University of California, San Francisco. He received his MMSc in biomedical informatics in 2015 from Harvard Medical School. Dr. Natarajan completed his internship and residency in internal medicine at the Brigham and Women’s Hospital, Harvard Medical School in 2011. He completed his clinical and research fellowship in cardiovascular medicine at the Massachusetts General Hospital, Harvard Medical School in 2015. Dr. Natarajan researches the inherited basis of human atherosclerosis using genetic epidemiology, large-scale sequencing studies, genotype-driven human investigation, and genetic testing implementation. In addition to his research efforts, Dr. Natarajan is a clinical cardiologist focusing on heart attack prevention, cardiovascular risk reduction, premature heart attack, lipid disorders, and cardiovascular genetics based at the MGH Cardiovascular Disease Prevention Center.

Presentation(s):

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