Concurrent Session 4C: Microbes and Cancer: The Microbiome’s Role in Carcinogenesis

Thursday, September 13
1:45 PM - 3:15 PM

Learning Objectives:

Moderator :
Heidi Nelson, MD

Professor of Surgery, College of Medicine and Science
Center for Individualized Medicine
Mayo Clinic
Rochester, Minnesota

Heidi Nelson, MD is the Fred C. Andersen Professor of Surgery at Mayo Clinic in Rochester, Minnesota, Chair of the Department of Surgery at Mayo Clinic, and past Chair of the Division of Colon and Rectal Surgery. Dr. Nelson earned her medical degree from the University of Washington School of Medicine, completed her General Surgery Residency at Oregon Health and Science University, and her fellowship training in Colon and Rectal Surgery at Mayo Clinic. Dr. Nelson’s long standing research interests parallel her clinical work in colon and rectal cancer. She was the PI of the NCI-grant and lead investigator for the NIH-funded laparoscopic colectomy for cancer trial. She has been the recipient of numerous nationally funded grants and is widely published in high impact journals. In addition to her own basic and clinical laboratory work she has held several research leadership roles including past program director within the Mayo Clinic Cancer Center and current director of the Mayo Microbiome Program in the Mayo Center for Individualized Medicine. Within the National Cancer Institute (NCI) Cooperative Groups she was the Vice Chair of the North Central Cancer Treatment Group and then served as a Group Chair of American College of Surgeons Oncology Group. She has been faculty for the AACR/ASCO Methods in Clinical Cancer Research Workshop for a three year term, a member and then chair of two NIH (NCI) study sections including, Subcommittee H (Cooperative Group Study Section), Clinical Oncology (CONC) and a member of the NCI Clinical Trials Advisory Committee.

Presentation(s):

Send Email for Heidi Nelson

Concurrent Speaker :
Christian Jobin, PhD

Professor
Medicine
University of Florida

Christian Jobin, PhD is the Gatorade Trust Professor of Medicine at the University of Florida Gainesville. He received his PhD in Immunology/Microbiology from Université Laval (Quebec, Canada) in 1994. He did a post-doctoral fellowship at the University of North Carolina Chapel Hill working on bacteria host interaction in the intestine. Dr. Jobin’s research focuses on establishing mechanisms controlling host-bacteria interaction in the intestine. His laboratory is especially interested in the functional impact of bacteria in inflammation and carcinogenesis. Using genetically engineered mice and zebrafish, germ-free and gnotobiotic technology in combinat ion with microbial genomics, his lab studies the role of bacteria in cancer. He has published over 150 scientific papers (Science, Nature, Nat. Comm., Nat. Micro., Immunity, J. Exp. Med., Gastroenterology) and presented his work at various national and international scientific meetings (>150 conferences). His research, supported by the National Institute of Health has led to numerous awards and honours (Mucosal Immunology Society Award, American Gastroenterological Association Fiterman Young Investigator Basic Research Award, UF Senior Faculty Excellence in Research Award). Dr. Jobin has served on several study sections including American Cancer Society, CCFA Fellowship and Career Awards, NIH tumor microenvironment and he is currently serving on the Gastrointestinal Mucosal Pathobiology study section (GMPB-permanent member).

Presentation(s):

Send Email for Christian Jobin

Concurrent Speaker :
Marina Walther-Antonio, PhD

Assistant Professor of Surgery, College of Medicine and Science
Center for Individualized Medicine
Mayo Clinic
Rochester, Minnesota

Marina Walther-Antonio, PhD is an Associate Consultant in the Department of Surgery and an Assistant Professor in the Microbiome Program at Mayo Clinic. She leads an interdisciplinary research program that studies the role of the human microbiome in women's health, and in gynecologic cancers in particular. In order to achieve this, Dr. Walther-Antonio and her research team have characterized the female reproductive tract microbiome in benign gynecologic conditions, cancer precursors, and endometrial and ovarian cancer manifestation. Their efforts have resulted in the identification of microbiota markers for endometrial cancer and in the development of translational approaches towards early detection and prevention of the disease. The ultimate goal is to pinpoint intervention opportunities that are amenable to modification of disease risk or can diminish the use of aggressive therapeutic options. Dr. Walther-Antonio’s ovarian cancer research is concentrated on the search for an early detection microbiome biomarker and mechanistic role in response to therapy involving monitoring during a clinical trial and patient derived xenograft mouse model. Because mechanistic microbiome studies benefit from complex host/microbe interrogation with a cellular level of resolution, the research team is also focused on the development and application of single-cell microfluidic technologies, such as Optofluidics and Digital Microfluidics.

Presentation(s):

Send Email for Marina Walther-Antonio

Concurrent Speaker - Int:
Meriem Messaoudene, PhD

Postdoctorant
Cancer
CRCHUM
Montreal, Quebec, Canada

Presentation(s):

Send Email for Meriem Messaoudene


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