Concurrent Session 4A: Individualizing Medicine: Sex Matters! CME (AMA PRA Category 1 CreditsTM) 1.5; CEU (NSGC category 1) 0.15; Attendance CEU 1.5

Thursday, September 13
1:45 PM - 3:15 PM
Location: Mayo Civic Center Rooms 102-103

The goal of genomics research is to maximize preventive, diagnostic, and treatment paradigms for each of us. This lofty goal cannot be accomplished unless there is greater understanding of how variants of genes on the sex chromosome (XX and XY) affect disease risk or how sex hormones (estrogen and testosterone) might affect gene expression or interfere with a particular therapy. This session will provide evidence of how the presence of genetic variants on the sex chromosome and on the autosomes associated with metabolisms affect your personalized care.

Learning Objectives:

Moderator :
Stacey J. Winham, PhD

Associate Professor of Biostatistics, College of Medicine and Science
Health Sciences Research
Mayo Clinic
Rochester, Minnesota

Stacey J. Winham, PhD was an NIH Building Interdisciplinary Research Careers in Women’s Health Scholar from 2013 to 2015, and is currently the recipient of the Walter and Evelyn Simmers Career Development Award for Ovarian Cancer Research. She is interested in the genetic factors underlying sex-specific effects, and particularly the role of the X chromosome. She develops statistical methods with applications in psychiatric genetics, and breast and ovarian cancer.

Dr. Winham is an Associate Professor of Biostatistics in the Department of Health Sciences Research. She received her PhD in statistics and statistical genetics from North Carolina State University in 2011. She came to Mayo Clinic in 2011, and is currently a Senior Associate Consultant II in the Division of Biomedical Statistics and Informatics.


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Post-Conference Speaker :
Mark O. Goodarzi, MD, PhD

Director, Division of Endocrinology, Diabetes and Metabolism
Department of Medicine
Cedars-Sinai Medical Center
Los Angeles, California

Mark O. Goodarzi, MD, PhD focuses his research efforts on identification of genetic factors underlying conditions related to insulin resistance and the metabolic syndrome, using population-based approaches. Major focus areas include the role of the gut microbiome in insulin resistance and insulin secretion, elucidation of genetic determinants of insulin clearance, insulin resistance and atherosclerosis in Hispanics, genetics studies in the polycystic ovary syndrome, and pharmacogenetics of the glycemic response to statins. Another research effort is characterization of the pathophysiology and genetics of pancreatogenic diabetes within the NIH-funded Consortium for the Study of Chronic Pancreatitis, Diabetes and Pancreatic Cancer.

Dr. Goodarzi is the Director of the Division of Endocrinology, Diabetes and Metabolism and Professor of Medicine at Cedars-Sinai Medical Center (CSMC) where he holds the Eris M. Field Chair in Diabetes Research. Dr. Goodarzi’s contributions were recognized by the Endocrine Society’s Richard E. Weitzman Memorial Award.


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Post-Conference Speaker :
Sabra L. Klein, PhD

Associate Professor
Molecular Microbiology and Immunology
Johns Hopkins Bloomberg School of Public Health
Baltimore, Maryland

Sabra L. Klein, PhD is a leading expert on sex differences in immune responses and susceptibility to infection and currently has over 100 peer-reviewed publications, authored several book chapters, and edited two books on the broad topics of sex differences in response to infection and treatments for infectious diseases. During the 2009 influenza pandemic, she was commissioned by the WHO to evaluate and publish a report on the impact of sex, gender, and pregnancy on the outcome of influenza virus infection. Dr. Klein has been invited to write reviews to introduce journal policies about sex reporting, wrote an Op Ed in the New York Times about sex-specific dosing of vaccines, and was lead author on an Opinion piece in PNAS defining the importance of sex as a biological variable in biomedical science. She is currently President-elect for the Organization for the Study of Sex Differences, which is the only scientific society dedicated to uncovering how males and females differ in health and disease. Her research has been highlighted in commentaries appearing in Proceedings of the National Academy of Sciences, Nature, and U.S. News and World Reports. Her research has been supported by grants from the National Institute of Allergy and Infectious Diseases, the National Science Foundation, and the National Foundation for Infectious Diseases. In 2010, she won the Society for Women’s Health Research Medtronic Award for Science Contributions, which recognized her scientific contributions as well as her commitment to mentoring other female scientists. In 2016, she received the Randolph-Macon College Distinguished Alumna Award.

Dr. Klein received her BA in Psychology from Randolph-Macon College, her MS from the University of Georgia in Biological Psychology, and her PhD in Behavioral Neuroscience from Johns Hopkins University. She did postdoctoral training at the Johns Hopkins Bloomberg School of Public Health in Molecular Microbiology and Immunology where she is now an Associate Professor.


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Concurrent Speaker :
Svetomic N. Markovic, MD, PhD

Division of Medical Oncology, Mayo Clinic


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Concurrent Session 4A: Individualizing Medicine: Sex Matters! CME (AMA PRA Category 1 CreditsTM) 1.5; CEU (NSGC category 1) 0.15; Attendance CEU 1.5


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Send Email for Concurrent Session 4A: Individualizing Medicine: Sex Matters! CME (AMA PRA Category 1 CreditsTM) 1.5; CEU (NSGC category 1) 0.15; Attendance CEU 1.5