Concurrent Session 4D: Artificial Intelligence in Medicine

Thursday, September 13
1:45 PM - 3:15 PM

Artificial Intelligence is already influencing a physician’s diagnostic decision making by generating “actionable intelligence” in patient-specific therapeutic choices.  This session will highlight recent successes and challenges in developing algorithmic and systems innovations for translation to the bedside.  

Concurrent Speaker :
Konstantinos Lazaridis, MD

Professor of Medicine, College of Medicine and Science
Center for Individualized Medicine
Mayo Clinic
Rochester, Minnesota

Konstantinos Lazaridis, MD is considered a leader in the area of the genomics of chronic cholestatic liver diseases, namely, Primary Biliary Cirrhosis (PBC) and Primary Sclerosing Cholangitis (PSC). Since 2003, he has established and is the principal investigator of the two national consortia for studying patients afflicted with these diseases. His research group applies the latest genomic and genetic epidemiology approaches to better understand the pathogenesis and improve the therapy of patients with PBC and PSC. This research effort is supported by the NIH. He was elected to the American Society of Clinical Investigation (ASCI) in 2015.

As associate director of the Center for Individualized Medicine in Rochester, Dr. Lazaridis has been instrumental in establishing and expanding the Individualized Medicine Clinic and in directing the Clinomics program that seeks to integrate the latest genomic discoveries into clinical care. Dr. Lazaridis is a physician in the Division of Gastroenterology and Hepatology and the Everett J. and Jane M. Hauck Associate Director, Center for Individualized Medicine, Mayo Clinic in Rochester. Dr. Lazaridis received his medical degree at the University of Ioannina in Greece. He completed his Internal Medicine and Gastroenterology fellowship training at Mayo Clinic and was a Mayo Clinic Scholar in Genomics in the laboratory of Dr. Francis Collins at the National Human Genome Research Institute.

Presentation(s):

Send Email for Konstantinos Lazaridis

Concurrent Speaker :
Arjun P. Athreya, MS

Fellow
Electrical and Computer Engineering
University of Illinois at Urbana-Champaign
Urbana, Illinois

Arjun Prasanna Athreya is a predoctoral Fellow in the department of Electrical and Computer Engineering (ECE) at the Univ. Illinois at Urbana-Champaign. Arjun is advised by Prof. Ravishankar K. Iyer in the DEPEND laboratory at the Coordinated Science Laboratory, and closely mentored by Drs. Richard Weinshilboum, Liewei Wang and William V. Bobo at Mayo Clinic. Arjun is also the inaugural Fellow of Mayo Clinic and Illinois Alliance for advancing Technology-based Healthcare Research. His research interests are in developing and applying machine learning/artificial intelligence methods on clinical and biological big data to bring predictability in clinical therapeutics to enable precision medicine. Arjun is currently developing analytical framework for precision medicine approaches in psychiatry, breast oncology and liver cancer. At the core of Arjun's work is the use of probabilistic graphical models in combination with other machine learning approaches that offer high-degrees of interpretability from a clinician's perspective and the developed framework is currently being engineered for deployment in several hospitals around the world. Arjun's collaboration extends to Max Planck Institute of Psychiatry, Germany, National University Hospital, Singapore and Emory University, USA. Prior to joining Univ. of Illinois, Arjun received his MS in ECE from Carnegie Mellon University, with interests in networks and system security.

Presentation(s):

Send Email for Arjun Athreya

Concurrent Speaker :
William V. Bobo, MD

Professor of Psychiatry, College of Medicine and Science
Psychiatry and Psychology
Mayo Clinic
Rochester, Minnesota

William V. Bobo, MD, MPH is Associate Professor of Psychiatry in the Mayo Clinic College of Medicine, Co-Chair for the Division of Outpatient Consultation in the Department of Psychiatry & Psychology at Mayo Clinic, and medical director of the Mayo Clinic Mood Disorders Program. He has published extensively on psychiatric epidemiology and pharmacoepidemiology, and clinical trials of pharmacotherapy for patients with severe mood disorders. He splits his time between patient care at the Mayo Clinic Depression Center, research, teaching of residents, and administrative duties.

Presentation(s):

Send Email for William Bobo

Concurrent Speaker :
Ravishankar Iyer, PhD

Professor
Electrical and Computer Engineering
University of Illinois at Urbana-Champaign
Urbana, Illinois

Ravishankar K. Iyer, PhD leads the DEPEND group at CSL which is focused on systems and software: deep measurement driven analytics combined with machine learning methods and data driven innovations with applications in two important domains: i) trust, and ii) health. Working closely with Mayo Clinic, Professor Iyer's DEPEND group has developed a rich data-driven analytics framework that is enabling discoveries in both clinical and biological settings. He currently co-leads the Computational Genomics Initiative at Illinois and is the PI for the Center for Computational Biology and Genomic Medicine CCGBM. The CCBGM develops and promotes collaboration between academia, industry, hospitals, and research laboratories to utilize the power of computational predictive genomics and advance pressing health care and related computational biotechnology issues of significant industrial interest. Also funded by an NSF MRI grant is a new computational platform to address both accuracy and performance issues for a range of genomics applications. The DEPEND group also has extensive expertise in data analytics in the system resilience and security domains - a domain where his group has won several awards and recognitions in both in advanced data analytics and resilient system design in critical infrastructures.

Dr. Iyer is the George and Ann Fisher Distinguished Professor of Engineering at the University of Illinois at Urbana-Champaign. He holds joint appointments in the Departments of Electrical and Computer Engineering and Computer Science, in the Coordinated Science Laboratory (CSL) the National Center for Supercomputing Applications, and the Carl R. Woese Institute for Genomic Biology. He is also a faculty Research Affiliate at the Mayo Clinic.

Presentation(s):

Send Email for Ravishankar Iyer

Concurrent Speaker :
Boadie W. Dunlop, MD

Associate Professor
Psychiatry and Behavioral Sciences
Emory University School of Medicine

Presentation(s):

Send Email for Boadie Dunlop

Concurrent Speaker :
Konstantinos Lazaridis, MD

Professor of Medicine, College of Medicine and Science
Center for Individualized Medicine
Mayo Clinic
Rochester, Minnesota

Konstantinos Lazaridis, MD is considered a leader in the area of the genomics of chronic cholestatic liver diseases, namely, Primary Biliary Cirrhosis (PBC) and Primary Sclerosing Cholangitis (PSC). Since 2003, he has established and is the principal investigator of the two national consortia for studying patients afflicted with these diseases. His research group applies the latest genomic and genetic epidemiology approaches to better understand the pathogenesis and improve the therapy of patients with PBC and PSC. This research effort is supported by the NIH. He was elected to the American Society of Clinical Investigation (ASCI) in 2015.

As associate director of the Center for Individualized Medicine in Rochester, Dr. Lazaridis has been instrumental in establishing and expanding the Individualized Medicine Clinic and in directing the Clinomics program that seeks to integrate the latest genomic discoveries into clinical care. Dr. Lazaridis is a physician in the Division of Gastroenterology and Hepatology and the Everett J. and Jane M. Hauck Associate Director, Center for Individualized Medicine, Mayo Clinic in Rochester. Dr. Lazaridis received his medical degree at the University of Ioannina in Greece. He completed his Internal Medicine and Gastroenterology fellowship training at Mayo Clinic and was a Mayo Clinic Scholar in Genomics in the laboratory of Dr. Francis Collins at the National Human Genome Research Institute.

Presentation(s):

Send Email for Konstantinos Lazaridis

Moderator :
Eric W. Klee, PhD

Senior Associate Consultant II
Center for Individualized Medicine; Department of Health Sciences Research; Department of Clinical Genomics, Mayo Clinic
Rochester, Minnesota

Eric W. Klee, PhD, is an Assistant Professor of Medical Informatics and Bioinformatics Program faculty member in the Department of Health Sciences Research, and has been at the Mayo Clinic since 2005. Dr. Klee is Director of Bioinformatics of Mayo Clinic’s Clinical Genome Sequencing Laboratory and member of the Department of Laboratory Medicine and Pathology, a position held since 2012. Dr. Klee is also the Associate Director of Mayo Clinic’s Center for Individualized Medicine Bioinformatics Program and has directed the Individualized Medicine Bioinformatics team since 2012.

Dr. Klee earned his Bachelors of Science degree in Electrical Engineering at Iowa State University in 1997, obtained a Master of Science degree in Health Informatics with focus in Bioinformatics at the University of Minnesota, Minneapolis. He went on to complete his PhD in Health Informatics and Bioinformatics in the University of Minnesota, Minneapolis, in 2005.

Dr. Klee’s research is focused on the application of next generation sequencing for clinical testing and diagnostics. His work includes the translation of emerging bioinformatics methods from the research domain into clinical practice. He is actively involved in the in development and implementation of systems to support sequence analysis and interpretation in the context of individualized, precision medicine. Dr. Klee also leads a functional validation program that uses experimental techniques to better characterize the putative role of variants of uncertain significance in the context of patient-specific disease state.

Presentation(s):

Send Email for Eric Klee


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