Concurrent Session 2D: Clinical RNA-seq: Oncologic and Hereditary Applications

Wednesday, September 12
1:30 PM - 3:00 PM

Moderator :
Eric W. Klee, PhD

Senior Associate Consultant II
Center for Individualized Medicine; Department of Health Sciences Research; Department of Clinical Genomics, Mayo Clinic
Rochester, Minnesota

Eric W. Klee, PhD, is an Assistant Professor of Medical Informatics and Bioinformatics Program faculty member in the Department of Health Sciences Research, and has been at the Mayo Clinic since 2005. Dr. Klee is Director of Bioinformatics of Mayo Clinic’s Clinical Genome Sequencing Laboratory and member of the Department of Laboratory Medicine and Pathology, a position held since 2012. Dr. Klee is also the Associate Director of Mayo Clinic’s Center for Individualized Medicine Bioinformatics Program and has directed the Individualized Medicine Bioinformatics team since 2012.

Dr. Klee earned his Bachelors of Science degree in Electrical Engineering at Iowa State University in 1997, obtained a Master of Science degree in Health Informatics with focus in Bioinformatics at the University of Minnesota, Minneapolis. He went on to complete his PhD in Health Informatics and Bioinformatics in the University of Minnesota, Minneapolis, in 2005.

Dr. Klee’s research is focused on the application of next generation sequencing for clinical testing and diagnostics. His work includes the translation of emerging bioinformatics methods from the research domain into clinical practice. He is actively involved in the in development and implementation of systems to support sequence analysis and interpretation in the context of individualized, precision medicine. Dr. Klee also leads a functional validation program that uses experimental techniques to better characterize the putative role of variants of uncertain significance in the context of patient-specific disease state.


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Concurrent Speaker :
William Fairbrother, PhD


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Concurrent Speaker :
Kevin C. Halling, MD, PhD

Co-Director of the Clinical Molecular Genetics Laboratory / Consultant, Divisions of Laboratory Genetics and Clinical Genomics
Mayo Clinic
Rochester, Minnesota

Kevin Halling, MD, PhD is a molecular pathologist and an Associate Professor in Mayo Clinic's Department of Laboratory Medicine in Rochester, MN. He directs the Clinical Molecular Genetics Laboratory which performs molecular oncology and hereditary disorder testing. He is also the Vice Chair for Research and Development for the department. He completed a PhD in Biochemistry and an MD at the University of Kansas. He did an Anatomic and Clinical pathology residency and Clinical Molecular Genetics fellowship at the Mayo Clinic. His primary area of interest is in the development of genetic tests that can be used for the diagnosis and treatment of sporadic and hereditary cancer. He and his team are currently working on the development of a clinical RNA Seq assay that can be used to detect gene fusions in patients with various types of malignancies. Dr. Halling has published over 100 papers that mostly relate to genetic testing of cancer.


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Concurrent Speaker :
Carl Koschmann, MD

Assistant Professor
Pediatric Hematology-Oncology
University of Michigan
Ann Arbor, Michigan

Carl Koschmann, MD is a Pediatric Neuro-Oncologist in the Department of Pediatrics and a Principal Investigator of a translational pediatric neuro-oncology laboratory at the University of Michigan. The Koschmann laboratory is exploring the molecular mechanisms by which recurrent mutations in pediatric high-grade glioma (HGG) and diffuse intrinsic pontine glioma (DIPG) promote tumor formation and affect treatment response. Along with researchers and colleagues from multiple divisions at the University of Michigan and other institutions, he developed and co-facilitates the UM CNS Precision Medicine conference. Dr. Koschmann has established new algorithms for targeted therapy selection and established multiple clinical trials incorporating the use of molecularly targeted therapy for pediatric patients with brain tumors. He will serve as PI for these trials and their biologic correlative research.


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Concurrent Session 2D: Clinical RNA-seq: Oncologic and Hereditary Applications

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