Concurrent Session 2B: Early Career Investigators in Precision Medicine; Attendance CEU 1.5 only

Wednesday, September 12
1:30 PM - 3:00 PM
Location: Mayo Civic Center Rooms 104-105

As a fairly new and quickly advancing field, individualized or precision medicine needs to attract students into the field to grow research in individual medicine and develop the clinicians who will help translate individualized medicine into patient care. This session offers an opportunity for early career investigators to present on their Precision Medicine research topics and outcomes of the research.

2018 Awardee Topics Include:

NaPi2b and HER2 as Precision Oncology Biomarkers and Targets for Antibody Drug Conjugate
Treatment of Biliary Tract Cancers (Bogenberger)

Relevance of Next Generation Sequencing in the Diagnosis of Inherited Bone Marrow Failure
Syndromes (Ferrer)

miRNA signature derived from GBM plasma exosomes as a diagnostic biomarker (Cumba Garcia)

Identifying de novo variants and genes potentially related with HLHS from 24 trios (Ge)

Synergistic Use of Rare Disease and Public Exome Databases Question the Nature of Minor
Non-Syndromic Long QT Syndrome-Susceptibility Gene-Disease Associations (Guidicessi)

Quantification and Evaluation of RAGE Using Targeted Multimodal Nanoparticles for the
Molecular Imaging of Prostate Cancer (Konopka)

Moderator :
Timothy B. Curry, MD, PhD

Director, Education Program
Center for Individualized Medicine
Mayo Clinic
Rochester, Minnesota

Timothy B. Curry, MD, PhD, is the Director of the Education Program of the Mayo Clinic Center for Individualized Medicine. A clinical anesthesiologist, he and his team are helping provide the education to support the translation of individualized medicine and develop the next generation of researchers and clinicians in personalized medicine.

Presentation(s):

Send Email for Timothy Curry

Concurrent Speaker :
James M. Bogenberger, PhD

Research Associate
Mayo Clinic
Scottsdale, Arizona

Presentation(s):

Send Email for James Bogenberger

Concurrent Speaker :
Luz M. Cumba Garcia, MSc

Student
Mayo Clinic Graduate School of Biomedical Sciences
Rochester, Minnesota

Presentation(s):

Send Email for Luz Cumba Garcia

Concurrent Speaker :
Alejandro Ferrer, PhD

Research Associate
Mayo Clinic
Rochester, Minnesota

Alejandro Ferrer, PhD is currently a research associate in the Center for Individualized Medicine (CIM) at Mayo Clinic in Rochester, Minnesota. His career started at the Center for Applied Medical Research in Pamplona, Spain where he obtained his PhD in Molecular Biology. His thesis work focused on the role of SLC4A2 in the etiopathogenesis of primary biliary cirrhosis, an autoimmune disease characterized by the development of antimitochondrial autoantibodies (AMA). This research described the immune phenotype of SLC4A2-knockout mice and confirmed that it mimics many of the features seen in humans, including the distinctive development of AMA. This research was funded by an individual grant from the Spanish Ministry of Education and Science, and was granted with the best young investigator poster presentation award at the European Association for the Study of the Liver 2012 Annual Meeting. After this, Dr. Ferrer accepted a position as a research fellow in the Immunology department at Mayo Clinic where he expanded his knowledge on the immune system by studying the activation of T cells through the TCR complex and the role of this mechanism on thymic development. Throughout this period, he was impressed by the work environment and values present at Mayo Clinic and in particular the continued focus on putting the needs of the patient first. This made him very interested in clinical research and encouraged him to find ways to use his skills to directly help patients. Dr. Ferrer found a position with these characteristics in the Center for Individualized Medicine, where he joined the Translational Genomic Program after becoming a Research Associate. For the last year, he has utilized his background in both molecular biology and immunology to analyze next generation sequencing data from patients with rare and undiagnosed diseases, taking special interest in inherited bone marrow failure syndromes. Dr. Ferrer uses state-of-the-art technology and any available resources with the sole purpose of diagnosing patients in a diagnostic odyssey and finding treatments for their afflictions. His goal is to pursue a long-term career in precision medicine because he believes this field contains the perfect equilibrium between basic and applied research and where his efforts result in improvement of patients’ lives.

Presentation(s):

Send Email for Alejandro Ferrer

Abstra:
Xiyu Ge

Student
Department of Molecular and Integrative Physiology
University of Illinois at Urbana-Champaign
Urbana, Illinois

Presentation(s):

Send Email for Xiyu Ge

Concurrent Speaker :
John R. Giudicessi, MD, PhD

Clinician Investigator Fellow
Department of Cardiovascular Medicine, Mayo Clinic
Rochester, Minnesota

Presentation(s):

Send Email for John Giudicessi

Abstra:
Christian J. Konopka

MD/PhD Candidate
University of Illinois at Urbana-Champaign
Urbana, Illinois

Christian Konopka is a 5th year MD/PhD student in the Medical Scholars Program at the University of Illinois at Urbana-Champaign, where he is performing research in the department of bioengineering. Christian received his BS in Biophysics from Loyola University Chicago, and conducted research, which focused on modeling the kinetics of DNA polymerase lambda when undergoing a base pair mismatch. During this time Christian also worked as a qEEG technologist and performed research correlating pathological qEEG findings to metabolic, genetic, and behavioral findings. Christian’s interest in research has evolved throughout his career, and he is now passionate about developing novel imaging agents and methods to improve cancer diagnosis and treatment. Specifically, he is interested in utilizing molecular imaging techniques to understand how the Receptor for Advanced Glycation End Products and its signaling axis play a role in the pathogenesis of prostate cancer. After his PhD, Christian will finish his MD and then hopes to specialize in radiation oncology.

Presentation(s):

Send Email for Christian Konopka


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