Innovation Showcase Thursday lunchtime
Live cell imaging of specialized cell types derived from stem cells holds much promise as a new approach to drug discovery and personalized medicine. In a long-term collaboration with Nikon Corporation, we have been using the BioStation CT to characterize disease-relevant neuronal subtypes, including motor neurons, dopaminergic neurons, and cortical neurons made from pluripotent cells engineered to express cell-type specific fluorescent reporters. These studies utilize live-cell imaging analysis to determine the cellular changes that underlie neurodegenerative diseases and to design and perform new types of drug screens. Measurements of neuronal properties, such as soma size and neurite growth, can be paired with single cell tracking for prolonged time courses (up to weeks). These studies have revealed some of the earliest morphological changes that foretell impending death. Further, we have identified properties of degenerating neurons that determine whether or not they can be rescued. These types of analyses provide the basis for a physiologically relevant human neuron-based approach to finding new treatments for neurodegenerative diseases.
Innovation Showcase: Nikon
11:30 - 12:30
Professor and Director of Translational Medicine Harvard University and the Harvard Stem Cell Institute
11:30 - 12:30
Innovation Showcase: QUANTIFYING NEURODEGENERATION USING LIVE CELL IMAGING - Nikon