Focus Session

Focus Session 3: BlueRock

Focus Session: BlueRock: USING PLURIPOTENT STEM CELLS TO TREAT DISEASES OF THE NERVOUS SYSTEM

6/20/2018
09:00 - 12:00

Presented by: BlueRock Therapeutics 

Presentations:

Stefan Irion

BlueRock Therapeutics

Stefan Irion, MD is the Senior Director, CNS Biology at BlueRock Therapeutics NYC laboratory. He received his MD from the University of Tuebingen in Germany and completed his postdoctoral fellowship with Dr. Gordon Keller. He then joined iPierian, a start-up using iPSC technologies, followed by a return to academia to work with Lorenz Studer and Viviane Tabar on a pluripotent stem cell-derived therapy for Parkinson's Disease. This technology was successfully licensed to BlueRock Therapeutics in 2016. Stefan has run pluripotent stem cells research programs in both academia and industry. He has lead projects in multiple therapeutic areas in a fast-paced startup environment at iPierian, where he demonstrated team building and people management skills. There, he developed an induced pluripotent stem cell model of Alzheimer's Disease that led to the discovery of a novel anti-tau antibody (IPN007). Bristol-Myers Squibb acquired iPierian in a $725M deal in 2014. BMS-986168 (IPN007) is now in clinical trials. He is the inventor of iPSC and genome editing patents. Currently, he is a member of the team that will bring MSK-DA01, the new Parkinson's Therapy, into the clinic and to patients. He is also responsible for advancing and developing BlueRock's pipeline of cell therapies for the nervous system

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Emile Nuwaysir

BlueRock Therapeutics

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Lorenz Studer

Memorial Sloan Kettering Cancer Center, NY, United States

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Evangelos Kiskinis

Northwestern University

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Steven A. Goldman

University of Copenhagen, Denmark and University of Rochester Medical Center, NY, United States

Steve Goldman is Professor of Neuroscience and Neurology at both the University of Copenhagen, and the University of Rochester Medical Center. In Copenhagen, he co-directs its Center for Translational Neuromedicine, while at Rochester, he is the URMC Distinguished Professor of Neuroscience and co-directs its Center for Translational Neuromedicine. Goldman obtained his PhD from Rockefeller University and his MD from Cornell, and did his residency in neurology at New York Hospital-Cornell and Memorial Sloan-Kettering. Goldman is interested in cell genesis in the adult brain, with a focus on the use of patient-specific stem and progenitor cells - and in particular their derived glia - in both modeling and treating those myelin disorders, neurodegenerative diseases and psychiatric conditions in which glial pathology is causally involved.

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Paul Tesar

Convelo Therapeutics & Case Western Reserve University School of Medicine, USA

Paul Tesar was born and raised in Cleveland, Ohio and received his undergraduate degree in biology from Case Western Reserve University. Paul went on to earn his DPhil (PhD) from the University of Oxford as a recipient of a prestigious scholarship from the National Institutes of Health.

His graduate studies, under the tutelage of Professor Sir Richard Gardner and Dr. Ron McKay, provided a paradigm shift on how we understand and utilize stem cells for research and medicine. This work culminated in a landmark paper in Nature describing the discovery of a new type of pluripotent stem cell, epiblast stem cells. This work stands among the most recognized in all of stem cell biology and earned Paul some of the highest graduate student accolades, including the Beddington Medal from the British Society for Developmental Biology and the Harold M. Weintraub Award from Fred Hutchinson Cancer Research Center.

Paul returned home to join the CWRU School of Medicine faculty in 2010 as a Mt. Sinai Health Care Foundation Scholar. Paul is currently a Professor and the Dr. Donald and Ruth Weber Goodman Professor of Innovative Therapeutics at CWRU School of Medicine in the Department of Genetics and Genome Sciences. His laboratory has pioneered new regenerative approaches to treat nervous system disorders including multiple sclerosis, neuromyelitis optica, pediatric leukodystrophies, cerebral palsy, and brain cancer.

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