Innovation Showcase Thursday lunchtime
Three dimensional (3-D) cell culture models are quickly being adopted for toxicology, drug discovery, and disease modeling. These models, including organoids, experience difficulties with variability, tissue viability, and experimental accessibility. Overcoming these obstacles is paramount for the logistical incorporation of 3-D tissues into high throughput toxicity and disease modeling workflows. In this showcase we introduce MimEX™ Tissue Model Systems, a new technology for the generation of sustainable and accessible 3-D human organ tissue. Using MimEX GI, a gastrointestinal model system, we demonstrate the principle and benefits of the technology, including methods for the efficient isolation, expansion, and differentiation of adult human “ground-state” stem cells from the gastrointestinal epithelium. The second part of the showcase focuses on the flexibility of MimEX Tissue Model Systems, including demonstrating how the technology can be used to generate 3-D models of other epithelial-derived organ tissues. In addition, we show that adult epithelial stem cells can be isolated from pathogenic tissue and will differentiate back into the diseased tissue in vitro, yielding a new method for modeling human disease.
Innovation Showcase: Bio-Techne
11:30 - 12:30
11:30 - 12:30
Innovation Showcase: UNFOLDING ORGANOIDS: A NEW PLATFORM FOR GENERATING ACCESSIBLE 3-D EPITHELIAL ORGAN TISSUE - Bio-Techne